Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms

Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms

Summary: STOX1 is a transcription factor involved in preeclampsia and Alzheimer disease. We show that the knock-down of the gene induces rather mild effect on gene expression in trophoblast cell lines (BeWo). We identified binding sites of STOX1 shared by the two major isoforms, STOX1A and STOX1B. P...

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Main Authors: Aurélien Ducat, Betty Couderc, Anthony Bouter, Louise Biquard, Rajaa Aouache, Bruno Passet, Ludivine Doridot, Marie-Benoîte Cohen, Pascale Ribaux, Clara Apicella, Irène Gaillard, Sophia Palfray, Yulian Chen, Alexandra Vargas, Amélie Julé, Léo Frelin, Julie Cocquet, Camino Ruano San Martin, Sébastien Jacques, Florence Busato, Jorg Tost, Céline Méhats, Paul Laissue, Jean-Luc Vilotte, Francisco Miralles, Daniel Vaiman
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Reproductive Medicine
Molecular Biology
Developmental Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302716

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