Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study
The purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/12/10/1758 |
| _version_ | 1797497305904971776 |
|---|---|
| author | Franz Wegner Kerstin Lüdtke-Buzug Sjef Cremers Thomas Friedrich Malte M. Sieren Julian Haegele Martin A. Koch Emine U. Saritas Paul Borm Thorsten M. Buzug Joerg Barkhausen Mandy Ahlborg |
| author_facet | Franz Wegner Kerstin Lüdtke-Buzug Sjef Cremers Thomas Friedrich Malte M. Sieren Julian Haegele Martin A. Koch Emine U. Saritas Paul Borm Thorsten M. Buzug Joerg Barkhausen Mandy Ahlborg |
| author_sort | Franz Wegner |
| collection | DOAJ |
| description | The purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings containing one of both particle types were fabricated and measured with a magnetic particle spectrometer (MPS) to estimate their MPI performance. Coatings based on both particle types were then applied on a segment of a nonmetallic guidewire. Imaging experiments were conducted using a commercial, preclinical MPI scanner and a preclinical 1 tesla MRI system. MPI image reconstruction was performed based on system matrices measured with dried KLB and Bayoxide E8706 coatings. The bimodal markers were clearly visible in both methods. They caused circular signal voids in MRI and areas of high signal intensity in MPI. Both the signal voids as well as the areas of high signal intensity were larger than the real marker size. Images that were reconstructed with a Bayoxide E8706 system matrix did not show sufficient MPI signal. Instrument markers with bimodal visibility are essential for the perspective of monitoring cardiovascular interventions with MPI/MRI hybrid systems. |
| first_indexed | 2024-03-10T03:15:38Z |
| format | Article |
| id | doaj.art-b5584ebac70c416d906d32a83c1f6beb |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:15:38Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b5584ebac70c416d906d32a83c1f6beb2023-11-23T12:27:47ZengMDPI AGNanomaterials2079-49912022-05-011210175810.3390/nano12101758Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept StudyFranz Wegner0Kerstin Lüdtke-Buzug1Sjef Cremers2Thomas Friedrich3Malte M. Sieren4Julian Haegele5Martin A. Koch6Emine U. Saritas7Paul Borm8Thorsten M. Buzug9Joerg Barkhausen10Mandy Ahlborg11Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, 23562 Luebeck, GermanyInstitute of Medical Engineering, University of Luebeck, 23538 Luebeck, GermanyNano4Imaging, 40225 Duesseldorf, GermanyInstitute of Medical Engineering, University of Luebeck, 23538 Luebeck, GermanyDepartment of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, 23562 Luebeck, GermanyZentrum für Radiologie und Nuklearmedizin, 04103 Dormagen, GermanyInstitute of Medical Engineering, University of Luebeck, 23538 Luebeck, GermanyDepartment of Electrical and Electronics Engineering, Bilkent University, 06800 Ankara, TurkeyNano4Imaging, 40225 Duesseldorf, GermanyInstitute of Medical Engineering, University of Luebeck, 23538 Luebeck, GermanyDepartment of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, 23562 Luebeck, GermanyInstitute of Medical Engineering, University of Luebeck, 23538 Luebeck, GermanyThe purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings containing one of both particle types were fabricated and measured with a magnetic particle spectrometer (MPS) to estimate their MPI performance. Coatings based on both particle types were then applied on a segment of a nonmetallic guidewire. Imaging experiments were conducted using a commercial, preclinical MPI scanner and a preclinical 1 tesla MRI system. MPI image reconstruction was performed based on system matrices measured with dried KLB and Bayoxide E8706 coatings. The bimodal markers were clearly visible in both methods. They caused circular signal voids in MRI and areas of high signal intensity in MPI. Both the signal voids as well as the areas of high signal intensity were larger than the real marker size. Images that were reconstructed with a Bayoxide E8706 system matrix did not show sufficient MPI signal. Instrument markers with bimodal visibility are essential for the perspective of monitoring cardiovascular interventions with MPI/MRI hybrid systems.https://www.mdpi.com/2079-4991/12/10/1758magnetic particle imagingmagnetic resonance imaginghybrid imagingnanoparticlesinterventional devicesendovascular interventions |
| spellingShingle | Franz Wegner Kerstin Lüdtke-Buzug Sjef Cremers Thomas Friedrich Malte M. Sieren Julian Haegele Martin A. Koch Emine U. Saritas Paul Borm Thorsten M. Buzug Joerg Barkhausen Mandy Ahlborg Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study Nanomaterials magnetic particle imaging magnetic resonance imaging hybrid imaging nanoparticles interventional devices endovascular interventions |
| title | Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study |
| title_full | Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study |
| title_fullStr | Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study |
| title_full_unstemmed | Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study |
| title_short | Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study |
| title_sort | bimodal interventional instrument markers for magnetic particle imaging and magnetic resonance imaging a proof of concept study |
| topic | magnetic particle imaging magnetic resonance imaging hybrid imaging nanoparticles interventional devices endovascular interventions |
| url | https://www.mdpi.com/2079-4991/12/10/1758 |
| work_keys_str_mv | AT franzwegner bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT kerstinludtkebuzug bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT sjefcremers bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT thomasfriedrich bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT maltemsieren bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT julianhaegele bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT martinakoch bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT emineusaritas bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT paulborm bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT thorstenmbuzug bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT joergbarkhausen bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy AT mandyahlborg bimodalinterventionalinstrumentmarkersformagneticparticleimagingandmagneticresonanceimagingaproofofconceptstudy |