Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (H...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2018-08-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100601&lng=en&tlng=en |
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| author | É.J.F. Peixoto de Miranda R.A. Hoshi M.S. Bittencourt A.C. Goulart I.S. Santos A.R. Brunoni M.F.H.S. Diniz A.L.P. Ribeiro E.M. Dantas J.G. Mill P.A. Lotufo I.M. Benseñor |
| author_facet | É.J.F. Peixoto de Miranda R.A. Hoshi M.S. Bittencourt A.C. Goulart I.S. Santos A.R. Brunoni M.F.H.S. Diniz A.L.P. Ribeiro E.M. Dantas J.G. Mill P.A. Lotufo I.M. Benseñor |
| author_sort | É.J.F. Peixoto de Miranda |
| collection | DOAJ |
| description | The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels. For HRV, the participants underwent 10 min in supine position and the R-R intervals of the final 5 min were selected for analysis. We first used linear regression models to report crude data and then, multivariate adjustment for sociodemographic (age, sex, and race) and cardiovascular risk factors (hypertension, dyslipidemia, diabetes, smoking, body mass index, use of alcohol, and leisure physical activity) using the euthyroid group as reference. From 9270 subjects (median age, 50; interquartile range: 44–56), 8623 (93.0%) were classified as euthyroid, 136 (1.5%) as SCHyper, and 511 (5.5%) as SCHypo. Compared to euthyroid subjects, SCHyper participants presented significantly higher heart rate (68.8 vs 66.5 for euthyroidism, P=0.007) and shorter R-R intervals (871.4 vs 901.6, P=0.007). Although SCHyper was associated with lower standard deviation of NN interval (SDNN) (β: –0.070; 95% confidence interval (95%CI): –0.014 to –0.009) and low-frequency (LF) (β: –0.242, 95%CI: –0.426 to –0.058) compared to the euthyroid group, these differences lost significance after multivariate adjustment for confounders. No significant differences were found for HRV in SCHypo. No association was found between HRV and SCHyper or SCHypo compared to euthyroid subjects in this sample of apparently healthy subjects. |
| first_indexed | 2024-12-11T01:53:56Z |
| format | Article |
| id | doaj.art-b55ee43586cf4e7ba13607d9230122b6 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-11T01:53:56Z |
| publishDate | 2018-08-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-b55ee43586cf4e7ba13607d9230122b62022-12-22T01:24:40ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2018-08-01511110.1590/1414-431x20187704S0100-879X2018001100601Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)É.J.F. Peixoto de MirandaR.A. HoshiM.S. BittencourtA.C. GoulartI.S. SantosA.R. BrunoniM.F.H.S. DinizA.L.P. RibeiroE.M. DantasJ.G. MillP.A. LotufoI.M. BenseñorThe association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels. For HRV, the participants underwent 10 min in supine position and the R-R intervals of the final 5 min were selected for analysis. We first used linear regression models to report crude data and then, multivariate adjustment for sociodemographic (age, sex, and race) and cardiovascular risk factors (hypertension, dyslipidemia, diabetes, smoking, body mass index, use of alcohol, and leisure physical activity) using the euthyroid group as reference. From 9270 subjects (median age, 50; interquartile range: 44–56), 8623 (93.0%) were classified as euthyroid, 136 (1.5%) as SCHyper, and 511 (5.5%) as SCHypo. Compared to euthyroid subjects, SCHyper participants presented significantly higher heart rate (68.8 vs 66.5 for euthyroidism, P=0.007) and shorter R-R intervals (871.4 vs 901.6, P=0.007). Although SCHyper was associated with lower standard deviation of NN interval (SDNN) (β: –0.070; 95% confidence interval (95%CI): –0.014 to –0.009) and low-frequency (LF) (β: –0.242, 95%CI: –0.426 to –0.058) compared to the euthyroid group, these differences lost significance after multivariate adjustment for confounders. No significant differences were found for HRV in SCHypo. No association was found between HRV and SCHyper or SCHypo compared to euthyroid subjects in this sample of apparently healthy subjects.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100601&lng=en&tlng=enSubclinical hypothyroidismSubclinical hyperthyroidismHeart rate variabilityAutonomic nervous system |
| spellingShingle | É.J.F. Peixoto de Miranda R.A. Hoshi M.S. Bittencourt A.C. Goulart I.S. Santos A.R. Brunoni M.F.H.S. Diniz A.L.P. Ribeiro E.M. Dantas J.G. Mill P.A. Lotufo I.M. Benseñor Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Brazilian Journal of Medical and Biological Research Subclinical hypothyroidism Subclinical hyperthyroidism Heart rate variability Autonomic nervous system |
| title | Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| title_full | Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| title_fullStr | Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| title_full_unstemmed | Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| title_short | Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| title_sort | relationship between heart rate variability and subclinical thyroid disorders of the brazilian longitudinal study of adult health elsa brasil |
| topic | Subclinical hypothyroidism Subclinical hyperthyroidism Heart rate variability Autonomic nervous system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100601&lng=en&tlng=en |
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