Computational Studies of Venom Peptides Targeting Potassium Channels
Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computatio...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-12-01
|
| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/7/12/4877 |
| _version_ | 1811297768200732672 |
|---|---|
| author | Rong Chen Shin-Ho Chung |
| author_facet | Rong Chen Shin-Ho Chung |
| author_sort | Rong Chen |
| collection | DOAJ |
| description | Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone. |
| first_indexed | 2024-04-13T06:09:09Z |
| format | Article |
| id | doaj.art-b55ee445c14e4c59ac9aaaa2a07af600 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T06:09:09Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-b55ee445c14e4c59ac9aaaa2a07af6002022-12-22T02:59:07ZengMDPI AGToxins2072-66512015-12-017125194521110.3390/toxins7124877toxins7124877Computational Studies of Venom Peptides Targeting Potassium ChannelsRong Chen0Shin-Ho Chung1Research School of Biology, Australian National University, Acton ACT 2601, AustraliaResearch School of Biology, Australian National University, Acton ACT 2601, AustraliaSmall peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone.http://www.mdpi.com/2072-6651/7/12/4877potassium channelspeptide toxinsmolecular modelingmolecular dynamics |
| spellingShingle | Rong Chen Shin-Ho Chung Computational Studies of Venom Peptides Targeting Potassium Channels Toxins potassium channels peptide toxins molecular modeling molecular dynamics |
| title | Computational Studies of Venom Peptides Targeting Potassium Channels |
| title_full | Computational Studies of Venom Peptides Targeting Potassium Channels |
| title_fullStr | Computational Studies of Venom Peptides Targeting Potassium Channels |
| title_full_unstemmed | Computational Studies of Venom Peptides Targeting Potassium Channels |
| title_short | Computational Studies of Venom Peptides Targeting Potassium Channels |
| title_sort | computational studies of venom peptides targeting potassium channels |
| topic | potassium channels peptide toxins molecular modeling molecular dynamics |
| url | http://www.mdpi.com/2072-6651/7/12/4877 |
| work_keys_str_mv | AT rongchen computationalstudiesofvenompeptidestargetingpotassiumchannels AT shinhochung computationalstudiesofvenompeptidestargetingpotassiumchannels |