Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices

Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices

Higher therapeutic concentrations of the antiseizure medication carbamazepine (CBZ) are associated with cognitive side effects. Hippocampal sharp wave-ripple complexes (SPW-Rs) are proposed to participate in memory consolidation during periods of quiet and slow-wave sleep. SPW-Rs are generated in th...

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Bibliographic Details
Main Authors: Timothy A. Simeone, Segewkal H. Heruye, Joseph A. Kostansek, Mary Y. Yeh, Stephanie A. Matthews, Kaeli K. Samson, Kristina A. Simeone
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Brain Sciences
Subjects:
cognitive impairment
epilepsy
adverse effect
high frequency oscillations
Online Access:https://www.mdpi.com/2076-3425/11/6/787

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