In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

Abstract Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of neurotoxicity and the impact of ALS-linked mutations (SOD1, FUS, TARDP, C9ORF72, PFN1, TUBA4A and others) have grea...

Full description

Bibliographic Details
Main Authors: Akshatha Ganne, Meenakshisundaram Balasubramaniam, Haarika Ayyadevara, Lily Kiaei, Robert J. Shmookler Reis, Kottayil I. Varughese, Mahmoud Kiaei
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28381-x

Similar Items

Similar Items