Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies
Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical University of Gdańsk
2023-06-01
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| Series: | European Journal of Translational and Clinical Medicine |
| Subjects: | |
| Online Access: | https://ejtcm.gumed.edu.pl/articles/166178.pdf |
| _version_ | 1797736100358258688 |
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| author | Sarah Gondek Mateusz Ogledzinski William Lin Kamila Milejczyk Braden Juengel Lisa Potter Piotr J. Bachul Lindsay Basto Laurencia Perea Ling-Jia Wang Martin Tibudan Zuzanna Witkowska Rolf Barth John Fung Piotr Witkowski |
| author_facet | Sarah Gondek Mateusz Ogledzinski William Lin Kamila Milejczyk Braden Juengel Lisa Potter Piotr J. Bachul Lindsay Basto Laurencia Perea Ling-Jia Wang Martin Tibudan Zuzanna Witkowska Rolf Barth John Fung Piotr Witkowski |
| author_sort | Sarah Gondek |
| collection | DOAJ |
| description | Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence. |
| first_indexed | 2024-03-12T13:08:41Z |
| format | Article |
| id | doaj.art-b5636b52b62747e2baa85d819f8073cb |
| institution | Directory Open Access Journal |
| issn | 2657-3148 2657-3156 |
| language | English |
| last_indexed | 2024-03-12T13:08:41Z |
| publishDate | 2023-06-01 |
| publisher | Medical University of Gdańsk |
| record_format | Article |
| series | European Journal of Translational and Clinical Medicine |
| spelling | doaj.art-b5636b52b62747e2baa85d819f8073cb2023-08-28T09:03:12ZengMedical University of GdańskEuropean Journal of Translational and Clinical Medicine2657-31482657-31562023-06-0161913166178Persistence of long-term insulin independence after islet transplantation and two subsequent pregnanciesSarah Gondek0https://orcid.org/0000-0003-0771-3217Mateusz Ogledzinski1https://orcid.org/0000-0002-1500-793XWilliam Lin2https://orcid.org/0009-0005-7819-4583Kamila Milejczyk3https://orcid.org/0009-0004-5723-864XBraden Juengel4https://orcid.org/0000-0002-5673-9344Lisa Potter5https://orcid.org/0000-0003-4489-3085Piotr J. Bachul6https://orcid.org/0000-0002-7694-1793Lindsay Basto7https://orcid.org/0000-0003-2168-2269Laurencia Perea8https://orcid.org/0000-0002-5936-8067Ling-Jia Wang9https://orcid.org/0000-0003-4536-8805Martin Tibudan10https://orcid.org/0000-0002-7674-4634Zuzanna Witkowska11https://orcid.org/0000-0002-7703-5717Rolf Barth12https://orcid.org/0000-0002-6770-5473John Fung13https://orcid.org/0000-0002-3038-0441Piotr Witkowski14https://orcid.org/0000-0002-4459-6673The Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAThe Transplantation Institute, University of Chicago, USAPregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.https://ejtcm.gumed.edu.pl/articles/166178.pdfpregnancyinsulinislet transplantation |
| spellingShingle | Sarah Gondek Mateusz Ogledzinski William Lin Kamila Milejczyk Braden Juengel Lisa Potter Piotr J. Bachul Lindsay Basto Laurencia Perea Ling-Jia Wang Martin Tibudan Zuzanna Witkowska Rolf Barth John Fung Piotr Witkowski Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies European Journal of Translational and Clinical Medicine pregnancy insulin islet transplantation |
| title | Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies |
| title_full | Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies |
| title_fullStr | Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies |
| title_full_unstemmed | Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies |
| title_short | Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies |
| title_sort | persistence of long term insulin independence after islet transplantation and two subsequent pregnancies |
| topic | pregnancy insulin islet transplantation |
| url | https://ejtcm.gumed.edu.pl/articles/166178.pdf |
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