Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022
Purpose: Data from the intensive care component of the German hospital infection surveillance system (KISS) was used to investigate the epidemiology of pathogens responsible for the most frequent device-associated infections and their development over time. Method: The 10 most common pathogens were...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | International Journal of Medical Microbiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S143842212300022X |
| _version_ | 1797256437599043584 |
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| author | Petra Gastmeier Axel Kola Frank Schwab Michael Behnke Christine Geffers |
| author_facet | Petra Gastmeier Axel Kola Frank Schwab Michael Behnke Christine Geffers |
| author_sort | Petra Gastmeier |
| collection | DOAJ |
| description | Purpose: Data from the intensive care component of the German hospital infection surveillance system (KISS) was used to investigate the epidemiology of pathogens responsible for the most frequent device-associated infections and their development over time. Method: The 10 most common pathogens were identified for ventilator-associated lower respiratory tract infections (VALRTI), catheter associated urinary tract infections (CAUTI), and central venous catheter associated bloodstream infections (CVC-BSI). The development over time was analyzed based on three five-year time periods: 2008–2012, 2013–2017, 2018–2022. Results: Data from 1425 ICUs were included together with 121,762 device-associated infections with 138,299 isolated pathogens. A remarkable and significant increase in the frequency of Klebsiella spp. was found for VALRTI, that was almost twice as high during 2018–2022 compared to 2008–2012. For CAUTI, there was a significant increase of all Enterobacterales with the most prominent increase in Klebsiella spp. With regard to CVC-BSI, the situation for coagulase-negative staphylococci and E. coli was relatively stable; while there was a significant increase in Enterococcus spp. and Klebsiella spp. and a decrease in S. aureus. Conclusion: Knowledge about the current frequency of pathogens responsible for nosocomial infections in intensive care units is important for guiding empirical antimicrobial therapy. Data from national nosocomial infection surveillance systems can provide relevant information about the development of pathogens. |
| first_indexed | 2024-03-08T18:43:13Z |
| format | Article |
| id | doaj.art-b566f6b8561b49e99998e082abbd16fd |
| institution | Directory Open Access Journal |
| issn | 1438-4221 |
| language | English |
| last_indexed | 2024-04-24T22:21:44Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Medical Microbiology |
| spelling | doaj.art-b566f6b8561b49e99998e082abbd16fd2024-03-20T06:08:43ZengElsevierInternational Journal of Medical Microbiology1438-42212024-03-01314151594Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022Petra Gastmeier0Axel Kola1Frank Schwab2Michael Behnke3Christine Geffers4Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany; National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, GermanyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany; National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, Germany; Corresponding author at: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany.Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany; National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, GermanyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany; National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, GermanyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Hindenburgdamm 27, 12203 Berlin, Germany; National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, GermanyPurpose: Data from the intensive care component of the German hospital infection surveillance system (KISS) was used to investigate the epidemiology of pathogens responsible for the most frequent device-associated infections and their development over time. Method: The 10 most common pathogens were identified for ventilator-associated lower respiratory tract infections (VALRTI), catheter associated urinary tract infections (CAUTI), and central venous catheter associated bloodstream infections (CVC-BSI). The development over time was analyzed based on three five-year time periods: 2008–2012, 2013–2017, 2018–2022. Results: Data from 1425 ICUs were included together with 121,762 device-associated infections with 138,299 isolated pathogens. A remarkable and significant increase in the frequency of Klebsiella spp. was found for VALRTI, that was almost twice as high during 2018–2022 compared to 2008–2012. For CAUTI, there was a significant increase of all Enterobacterales with the most prominent increase in Klebsiella spp. With regard to CVC-BSI, the situation for coagulase-negative staphylococci and E. coli was relatively stable; while there was a significant increase in Enterococcus spp. and Klebsiella spp. and a decrease in S. aureus. Conclusion: Knowledge about the current frequency of pathogens responsible for nosocomial infections in intensive care units is important for guiding empirical antimicrobial therapy. Data from national nosocomial infection surveillance systems can provide relevant information about the development of pathogens.http://www.sciencedirect.com/science/article/pii/S143842212300022XNosocomial infectionsPathogenIntensive careBloodstream infectionsPneumoniaUrinary tract infections |
| spellingShingle | Petra Gastmeier Axel Kola Frank Schwab Michael Behnke Christine Geffers Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 International Journal of Medical Microbiology Nosocomial infections Pathogen Intensive care Bloodstream infections Pneumonia Urinary tract infections |
| title | Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 |
| title_full | Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 |
| title_fullStr | Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 |
| title_full_unstemmed | Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 |
| title_short | Etiology of nosocomial infections in intensive care patients in German hospitals: An analysis of trends between 2008 and 2022 |
| title_sort | etiology of nosocomial infections in intensive care patients in german hospitals an analysis of trends between 2008 and 2022 |
| topic | Nosocomial infections Pathogen Intensive care Bloodstream infections Pneumonia Urinary tract infections |
| url | http://www.sciencedirect.com/science/article/pii/S143842212300022X |
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