Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer
<p>Abstract</p> <p>Background</p> <p>To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.</p> <p>Methods<...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/12/175 |
| _version_ | 1818960706127527936 |
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| author | Nguyen Nam P Vos Paul Vinh-Hung Vincent Ceizyk Misty Smith-Raymond Lexie Stevie Michelle Slane Benjamin Chi Alexander Desai Anand Krafft Shane P Jang Siyoung Hamilton Russ Karlsson Ulf Abraham Dave |
| author_facet | Nguyen Nam P Vos Paul Vinh-Hung Vincent Ceizyk Misty Smith-Raymond Lexie Stevie Michelle Slane Benjamin Chi Alexander Desai Anand Krafft Shane P Jang Siyoung Hamilton Russ Karlsson Ulf Abraham Dave |
| author_sort | Nguyen Nam P |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.</p> <p>Methods</p> <p>A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.</p> <p>Results</p> <p>Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40 Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20 Gy on parotid dose <b>(</b>23 patients) and the conventional constraint (CC) of 26 Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1 Gy and 24.7 Gy for the SC and CC plans (<it>p</it> < 0.0001). The volume of contralateral parotid receiving 40 Gy or more was respectively 5.3% and 18.2% (<it>p</it> < 0.0001)</p> <p>Conclusion</p> <p>Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.</p> |
| first_indexed | 2024-12-20T12:01:47Z |
| format | Article |
| id | doaj.art-b567920ae47c431bbe5d74fd91eb10e0 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T12:01:47Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-b567920ae47c431bbe5d74fd91eb10e02022-12-21T19:41:32ZengBMCBMC Cancer1471-24072012-05-0112117510.1186/1471-2407-12-175Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancerNguyen Nam PVos PaulVinh-Hung VincentCeizyk MistySmith-Raymond LexieStevie MichelleSlane BenjaminChi AlexanderDesai AnandKrafft Shane PJang SiyoungHamilton RussKarlsson UlfAbraham Dave<p>Abstract</p> <p>Background</p> <p>To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.</p> <p>Methods</p> <p>A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.</p> <p>Results</p> <p>Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40 Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20 Gy on parotid dose <b>(</b>23 patients) and the conventional constraint (CC) of 26 Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1 Gy and 24.7 Gy for the SC and CC plans (<it>p</it> < 0.0001). The volume of contralateral parotid receiving 40 Gy or more was respectively 5.3% and 18.2% (<it>p</it> < 0.0001)</p> <p>Conclusion</p> <p>Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.</p>http://www.biomedcentral.com/1471-2407/12/175Head and neck cancerTomotherapyParotid sparing |
| spellingShingle | Nguyen Nam P Vos Paul Vinh-Hung Vincent Ceizyk Misty Smith-Raymond Lexie Stevie Michelle Slane Benjamin Chi Alexander Desai Anand Krafft Shane P Jang Siyoung Hamilton Russ Karlsson Ulf Abraham Dave Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer BMC Cancer Head and neck cancer Tomotherapy Parotid sparing |
| title | Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| title_full | Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| title_fullStr | Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| title_full_unstemmed | Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| title_short | Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| title_sort | feasibility of image guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer |
| topic | Head and neck cancer Tomotherapy Parotid sparing |
| url | http://www.biomedcentral.com/1471-2407/12/175 |
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