Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge
Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring’s neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been rela...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1320319/full |
| _version_ | 1827387807999459328 |
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| author | Sara Manti Giulia Spoto Antonio Gennaro Nicotera Gabriella Di Rosa Giovanni Piedimonte |
| author_facet | Sara Manti Giulia Spoto Antonio Gennaro Nicotera Gabriella Di Rosa Giovanni Piedimonte |
| author_sort | Sara Manti |
| collection | DOAJ |
| description | Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring’s neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been related to numerous neuropsychiatric sequelae. Respiratory viruses can disrupt brain development by directly invading the fetal circulation through vertical transmission or inducing neuroinflammation through the maternal immune activation and production of inflammatory cytokines. Influenza virus gestational infection has been consistently associated with psychotic disorders, such as schizophrenia and autism spectrum disorder, while the recent pandemic raised some concerns regarding the effects of severe acute respiratory syndrome coronavirus 2 on neurodevelopmental outcomes of children born to affected mothers. In addition, emerging evidence supports the possible role of respiratory syncytial virus infection as a risk factor for adverse neuropsychiatric consequences. Understanding the mechanisms underlying developmental dysfunction allows for improving preventive strategies, early diagnosis, and prompt interventions. |
| first_indexed | 2024-03-08T16:07:40Z |
| format | Article |
| id | doaj.art-b56900f9f8f34684bfbf91c5ec4d958e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T16:07:40Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b56900f9f8f34684bfbf91c5ec4d958e2024-01-08T04:50:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-01-011710.3389/fnins.2023.13203191320319Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledgeSara Manti0Giulia Spoto1Antonio Gennaro Nicotera2Gabriella Di Rosa3Giovanni Piedimonte4Pediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Biomedical and Dental Sciences and of Morphological and Functional Imaging, University of Messina, Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Messina, ItalyUnit of Child Neurology and Psychiatry, Department of Biomedical and Dental Sciences and of Morphological and Functional Imaging, University of Messina, Messina, ItalyDepartment of Pediatrics, Biochemistry and Molecular Biology, Tulane University, New Orleans, LA, United StatesBrain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring’s neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been related to numerous neuropsychiatric sequelae. Respiratory viruses can disrupt brain development by directly invading the fetal circulation through vertical transmission or inducing neuroinflammation through the maternal immune activation and production of inflammatory cytokines. Influenza virus gestational infection has been consistently associated with psychotic disorders, such as schizophrenia and autism spectrum disorder, while the recent pandemic raised some concerns regarding the effects of severe acute respiratory syndrome coronavirus 2 on neurodevelopmental outcomes of children born to affected mothers. In addition, emerging evidence supports the possible role of respiratory syncytial virus infection as a risk factor for adverse neuropsychiatric consequences. Understanding the mechanisms underlying developmental dysfunction allows for improving preventive strategies, early diagnosis, and prompt interventions.https://www.frontiersin.org/articles/10.3389/fnins.2023.1320319/fullinfluenza virusmaternal infectionneurodevelopmental outcomerespiratory syncytial virusrespiratory viral infectionssevere acute respiratory syndrome coronavirus 2 |
| spellingShingle | Sara Manti Giulia Spoto Antonio Gennaro Nicotera Gabriella Di Rosa Giovanni Piedimonte Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge Frontiers in Neuroscience influenza virus maternal infection neurodevelopmental outcome respiratory syncytial virus respiratory viral infections severe acute respiratory syndrome coronavirus 2 |
| title | Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge |
| title_full | Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge |
| title_fullStr | Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge |
| title_full_unstemmed | Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge |
| title_short | Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge |
| title_sort | impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn current knowledge |
| topic | influenza virus maternal infection neurodevelopmental outcome respiratory syncytial virus respiratory viral infections severe acute respiratory syndrome coronavirus 2 |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1320319/full |
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