Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study
Abdallah Damin Abukhalil, Ola Ali,* Asmaa Saad,* Hiba Falana, Ni’meh Al-Shami, Hani A Naseef, Abdullah Rabba Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzeit, West Bank, Palestine*These authors contributed equally to this w...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-01-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/evaluation-of-proton-pump-inhibitors-prescribing-among-hospitalized-pa-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797954474665312256 |
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| author | Abukhalil AD Ali O Saad A Falana H Al-Shami N Naseef HA Rabba A |
| author_facet | Abukhalil AD Ali O Saad A Falana H Al-Shami N Naseef HA Rabba A |
| author_sort | Abukhalil AD |
| collection | DOAJ |
| description | Abdallah Damin Abukhalil, Ola Ali,* Asmaa Saad,* Hiba Falana, Ni’meh Al-Shami, Hani A Naseef, Abdullah Rabba Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzeit, West Bank, Palestine*These authors contributed equally to this workCorrespondence: Abdallah Damin Abukhalil; Hiba Falana, Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzeit, West Bank, Palestine, Tel +970-5-98204036 ; +970-5-9519486, Fax +970-2-2982017, Email Adkhalil@birzeit.edu; hibafalana@birzeit.eduBackground: Proton pump inhibitors (PPIs) are the most effective agents for managing acid-related disorders. However, inappropriate prescribing of PPIs is becoming an issue of concern.Objective: This study aimed to assess the appropriate utilization of PPIs in terms of indication, dose, frequency, and route of administration during admission and discharge. Furthermore, direct costs associated with inappropriate PPI use were calculated.Methods: A descriptive cross-sectional study was conducted at the internal medicine department of a tertiary hospital in Palestine from January 1, 2021, to June 30, 2021. The medical records of patients aged 18 years or older, hospitalized for 48 hours or more, and receiving oral or intravenous (IV) PPIs during their stay were collected and evaluated for the appropriateness of PPIs prescribed according to clinical guidelines.Results: Of 262 patients, 80.2% had an appropriate indication for prophylaxis (67.6%) or treatment (12.6%). A total of 230 patients were prescribed IV pantoprazole.182 (79.1%) had an appropriate indication, whereas 122/182 (67%) received IV PPI instead of oral without an appropriate indication. Of the 32 patients who received 20 mg of oral omeprazole, 28 (87.5%) had an appropriate indication, dose, and route of administration, whereas 16/28 (57.1%) had an inappropriate frequency. At discharge, 32.5% of patients were discharged with unnecessary PPI prescriptions. The total direct cost of inappropriate PPI Indications and route of administration in 188 patients over six months was $1518.Conclusion: This study showed that most patients received a PPI for an appropriate indication with the correct dose. However, a high prevalence of inappropriate IV pantoprazole administration was observed, resulting in the highest costs, demonstrating the importance of correctly ordering IV medications. Adherence to clinical guidelines, such as those of the American College of Gastroenterology (ACG), will improve the appropriateness of PPI prescribing, prevent complications, and reduce healthcare costs.Keywords: PPIs, proton pump inhibitors, indication, IV-PO switch, cost-saving, pantoprazole, omeprazole, Palestine |
| first_indexed | 2024-04-10T23:17:57Z |
| format | Article |
| id | doaj.art-b569113bef6f4f039338ea6d7edff96c |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-10T23:17:57Z |
| publishDate | 2023-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-b569113bef6f4f039338ea6d7edff96c2023-01-12T18:03:06ZengDove Medical PressInternational Journal of General Medicine1178-70742023-01-01Volume 1614115080940Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional StudyAbukhalil ADAli OSaad AFalana HAl-Shami NNaseef HARabba AAbdallah Damin Abukhalil, Ola Ali,* Asmaa Saad,* Hiba Falana, Ni’meh Al-Shami, Hani A Naseef, Abdullah Rabba Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzeit, West Bank, Palestine*These authors contributed equally to this workCorrespondence: Abdallah Damin Abukhalil; Hiba Falana, Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzeit, West Bank, Palestine, Tel +970-5-98204036 ; +970-5-9519486, Fax +970-2-2982017, Email Adkhalil@birzeit.edu; hibafalana@birzeit.eduBackground: Proton pump inhibitors (PPIs) are the most effective agents for managing acid-related disorders. However, inappropriate prescribing of PPIs is becoming an issue of concern.Objective: This study aimed to assess the appropriate utilization of PPIs in terms of indication, dose, frequency, and route of administration during admission and discharge. Furthermore, direct costs associated with inappropriate PPI use were calculated.Methods: A descriptive cross-sectional study was conducted at the internal medicine department of a tertiary hospital in Palestine from January 1, 2021, to June 30, 2021. The medical records of patients aged 18 years or older, hospitalized for 48 hours or more, and receiving oral or intravenous (IV) PPIs during their stay were collected and evaluated for the appropriateness of PPIs prescribed according to clinical guidelines.Results: Of 262 patients, 80.2% had an appropriate indication for prophylaxis (67.6%) or treatment (12.6%). A total of 230 patients were prescribed IV pantoprazole.182 (79.1%) had an appropriate indication, whereas 122/182 (67%) received IV PPI instead of oral without an appropriate indication. Of the 32 patients who received 20 mg of oral omeprazole, 28 (87.5%) had an appropriate indication, dose, and route of administration, whereas 16/28 (57.1%) had an inappropriate frequency. At discharge, 32.5% of patients were discharged with unnecessary PPI prescriptions. The total direct cost of inappropriate PPI Indications and route of administration in 188 patients over six months was $1518.Conclusion: This study showed that most patients received a PPI for an appropriate indication with the correct dose. However, a high prevalence of inappropriate IV pantoprazole administration was observed, resulting in the highest costs, demonstrating the importance of correctly ordering IV medications. Adherence to clinical guidelines, such as those of the American College of Gastroenterology (ACG), will improve the appropriateness of PPI prescribing, prevent complications, and reduce healthcare costs.Keywords: PPIs, proton pump inhibitors, indication, IV-PO switch, cost-saving, pantoprazole, omeprazole, Palestinehttps://www.dovepress.com/evaluation-of-proton-pump-inhibitors-prescribing-among-hospitalized-pa-peer-reviewed-fulltext-article-IJGMppisproton pump inhibitorsindicationiv-po switchcost-savingpantoprazoleomeprazolepalestine |
| spellingShingle | Abukhalil AD Ali O Saad A Falana H Al-Shami N Naseef HA Rabba A Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study International Journal of General Medicine ppis proton pump inhibitors indication iv-po switch cost-saving pantoprazole omeprazole palestine |
| title | Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study |
| title_full | Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study |
| title_fullStr | Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study |
| title_full_unstemmed | Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study |
| title_short | Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study |
| title_sort | evaluation of proton pump inhibitors prescribing among hospitalized patients a cross sectional study |
| topic | ppis proton pump inhibitors indication iv-po switch cost-saving pantoprazole omeprazole palestine |
| url | https://www.dovepress.com/evaluation-of-proton-pump-inhibitors-prescribing-among-hospitalized-pa-peer-reviewed-fulltext-article-IJGM |
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