Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.

Alterations in DNA damage response and repair have been observed in Huntington's disease (HD). We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. A significant fraction of the HD iPSC lines had genomic abnormalities a...

Full description

Bibliographic Details
Main Authors:	Andrew M Tidball, M Diana Neely, Reed Chamberlin, Asad A Aboud, Kevin K Kumar, Bingying Han, Miles R Bryan, Michael Aschner, Kevin C Ess, Aaron B Bowman
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4794230?pdf=render

Similar Items

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation
by: Narasimhachar Srinivasakumar, et al.
Published: (2013-12-01)

Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism.
by: Jennifer L Madison, et al.
Published: (2012-01-01)

SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells
by: Ghiselli Giancarlo
Published: (2006-11-01)

p53 activation by knockdown technologies.
by: Mara E Robu, et al.
Published: (2007-05-01)

Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin
by: Veniamin Y. Sidorov, et al.
Published: (2024-02-01)

Effects of Klf4 and c-Myc Knockdown on Pluripotency Maintenance in Porcine Induced Pluripotent Stem Cell
by: Yu-Jing Liao, et al.
Published: (2017-11-01)

Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells
by: Emma K. Hollmann, et al.
Published: (2017-04-01)

MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.
by: Stéphanie Tomé, et al.
Published: (2013-01-01)

Generation of induced pluripotent stem cells from three individuals with Huntington‘s disease
by: Duncan C. Miller, et al.
Published: (2022-12-01)

A platform for studies of Huntington’s disease on the basis of induced pluripotent stem cells
by: E. D. Nekrasov, et al.
Published: (2017-02-01)

Impact of p53 knockdown on protein dataset of HaCaT cells
by: Daniil D. Romashin, et al.
Published: (2022-06-01)

Functions of p53 in pluripotent stem cells
by: Xuemei Fu, et al.
Published: (2019-11-01)

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish
by: Seok-Hyung Kim, et al.
Published: (2013-07-01)

Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.
by: Anup K Kundu, et al.
Published: (2017-01-01)

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.
by: Mangiarini, L, et al.
Published: (1997)

POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim
by: Chun-Hua Wang, et al.
Published: (2018-05-01)

CAG Repeat Instability in the Peripheral and Central Nervous System of Transgenic Huntington’s Disease Monkeys
by: In K. Cho, et al.
Published: (2022-08-01)

Commentary: Acanthocytes identified in Huntington's disease
by: Kevin Peikert, et al.
Published: (2022-11-01)

Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis
by: Amy B. Ryan, et al.
Published: (2006-11-01)

Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells.
by: Yanhong Zhang, et al.
Published: (2013-01-01)

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease
by: Alba Di Pardo, et al.
Published: (2017-07-01)

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.
by: Tuoen Liu, et al.
Published: (2017-01-01)

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice
by: Marina Kovalenko, et al.
Published: (2020-09-01)

Dynamic instability of genomic methylation patterns in pluripotent stem cells
by: Ooi Steen KT, et al.
Published: (2010-09-01)

Alterations in metal homeostasis occur prior to canonical markers in Huntington disease
by: Anna C. Pfalzer, et al.
Published: (2022-06-01)

Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
by: Rachel H. Mansky, et al.
Published: (2023-03-01)

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
by: Juopperi Tarja A, et al.
Published: (2012-05-01)

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
by: Seda Koyuncu, et al.
Published: (2018-07-01)

Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells
by: Alexandra V. Goodnight, et al.
Published: (2019-11-01)

Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells
by: Richard L. Carter, et al.
Published: (2014-10-01)

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
by: Augustine, George James, et al.
Published: (2017)

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
by: Xiaohong Xu, et al.
Published: (2017-03-01)

Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.
by: Fei, P, et al.
Published: (2004)

Knockdown of GmD53a confers strigolactones mediated rhizobia interaction and promotes nodulation in soybean
by: Naveed Rehman, et al.
Published: (2022-01-01)

Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway
by: Cai Q, et al.
Published: (2023-11-01)

Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.
by: Khaled N Alsayegh, et al.
Published: (2015-01-01)

Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence.
by: Asish K Ghosh, et al.
Published: (2008-01-01)

Minimal prevalence of Huntington’s disease in the South of Brazil and instability of the expanded CAG tract during intergenerational transmissions
by: Raphael Machado de Castilhos, et al.

Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells
by: Haifeng Fu, et al.
Published: (2021-07-01)

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
by: Daniel Bronder, et al.
Published: (2021-11-01)