Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers
Many biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-03-01
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| Series: | Advanced Intelligent Systems |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aisy.201900124 |
| _version_ | 1811325007324774400 |
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| author | Ya Xiong Lin Qi Ye Niu Yueqiang Lin Qingzhong Xue Yi Zhao |
| author_facet | Ya Xiong Lin Qi Ye Niu Yueqiang Lin Qingzhong Xue Yi Zhao |
| author_sort | Ya Xiong |
| collection | DOAJ |
| description | Many biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and temperature. Autonomous drug release that uses one or more of these disease symptom‐associated properties as the release trigger minimizes the delay in treatments and allows for the release of medications with precisely controlled amounts and with desired spatiotemporal patterns. Herein, a comprehensive assessment of current research progress on autonomous drug release systems (ADRS) is provided. The representative symptoms‐associated properties that can be potentially used as the endogenous stimuli are introduced. The autonomous drug systems that utilize these symptom‐associated signals as the endogenous stimulation signals are discussed, followed by the discussion of current challenges and opportunities in this field, as well as possible future directions in ADRS. |
| first_indexed | 2024-04-13T14:25:36Z |
| format | Article |
| id | doaj.art-b56a142b9eb4473590f020bd47fbe1aa |
| institution | Directory Open Access Journal |
| issn | 2640-4567 |
| language | English |
| last_indexed | 2024-04-13T14:25:36Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Intelligent Systems |
| spelling | doaj.art-b56a142b9eb4473590f020bd47fbe1aa2022-12-22T02:43:21ZengWileyAdvanced Intelligent Systems2640-45672020-03-0123n/an/a10.1002/aisy.201900124Autonomous Drug Release Systems with Disease Symptom‐Associated TriggersYa Xiong0Lin Qi1Ye Niu2Yueqiang Lin3Qingzhong Xue4Yi Zhao5Department of Biomedical Engineering The Ohio State University Columbus OH 43210 USADepartment of Biomedical Engineering The Ohio State University Columbus OH 43210 USADepartment of Biomedical Engineering The Ohio State University Columbus OH 43210 USADepartment of Biomedical Engineering The Ohio State University Columbus OH 43210 USADepartment of Materials Science and Engineering China University of Petroleum Qingdao 266580 Shandong P. R. ChinaDepartment of Biomedical Engineering The Ohio State University Columbus OH 43210 USAMany biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and temperature. Autonomous drug release that uses one or more of these disease symptom‐associated properties as the release trigger minimizes the delay in treatments and allows for the release of medications with precisely controlled amounts and with desired spatiotemporal patterns. Herein, a comprehensive assessment of current research progress on autonomous drug release systems (ADRS) is provided. The representative symptoms‐associated properties that can be potentially used as the endogenous stimuli are introduced. The autonomous drug systems that utilize these symptom‐associated signals as the endogenous stimulation signals are discussed, followed by the discussion of current challenges and opportunities in this field, as well as possible future directions in ADRS.https://doi.org/10.1002/aisy.201900124autonomous drug administrationbiophysical propertiescontrolled drug releasehydrogelsnanocarrierssmart systems |
| spellingShingle | Ya Xiong Lin Qi Ye Niu Yueqiang Lin Qingzhong Xue Yi Zhao Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers Advanced Intelligent Systems autonomous drug administration biophysical properties controlled drug release hydrogels nanocarriers smart systems |
| title | Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers |
| title_full | Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers |
| title_fullStr | Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers |
| title_full_unstemmed | Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers |
| title_short | Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers |
| title_sort | autonomous drug release systems with disease symptom associated triggers |
| topic | autonomous drug administration biophysical properties controlled drug release hydrogels nanocarriers smart systems |
| url | https://doi.org/10.1002/aisy.201900124 |
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