Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS)
Abstract Background Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) sometimes present with stiffness of the cervical muscles. To investigate the pathophysiology of ME/CFS, this observational study compared patients with versus without recovery from ME/CFS through local mo...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-021-04293-7 |
| _version_ | 1830373838371684352 |
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| author | Takayoshi Matsui Kazuhiro Hara Makoto Iwata Shuntaro Hojo Nobuyuki Shitara Yuzo Endo Hideoki Fukuoka Masaki Matsui Hiroshi Kawaguchi |
| author_facet | Takayoshi Matsui Kazuhiro Hara Makoto Iwata Shuntaro Hojo Nobuyuki Shitara Yuzo Endo Hideoki Fukuoka Masaki Matsui Hiroshi Kawaguchi |
| author_sort | Takayoshi Matsui |
| collection | DOAJ |
| description | Abstract Background Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) sometimes present with stiffness of the cervical muscles. To investigate the pathophysiology of ME/CFS, this observational study compared patients with versus without recovery from ME/CFS through local modulation of the cervical muscles. Methods Over a period of 11 years, a total of 1226 inpatients with ME/CFS who did not respond to outpatient care were enrolled in this study. All patients received daily cervical muscle physical therapy during hospitalization. Self-rated records documenting the presence or absence of ME/CFS, as well as the representative eight symptoms that frequently accompany it at admission and discharge, were compared. Pupil diameter was also measured to examine autonomic nervous system function involvement. Results The recovery rate of ME/CFS after local therapy was 55.5%, and did not differ significantly by sex, age strata, and hospitalization period. The recovery rates of the eight symptoms were variable (36.6–86.9%); however, those of ME/CFS in the symptom subpopulations were similar (52.3–55.8%). The recovery rates of all symptoms showed strong associations with that of ME/CFS (p < 0.001). The pupil diameter was more constricted in the ME/CFS-recovered patients than in the ME/CFS-unrecovered patients in the total population and the subpopulations stratified by sex, age, and hospitalization period. Conclusions There was a strong association between the recovery of ME/CFS and other related whole-body symptoms. The recovery of ME/CFS may be partly linked to amelioration of the autonomic nervous system in the cervical muscles. Trial registration UMIN000036634 . Registered 1 May 2019 - Retrospectively registered. |
| first_indexed | 2024-12-20T07:25:49Z |
| format | Article |
| id | doaj.art-b56b65746f2744d287fc01d504d5e8c4 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-20T07:25:49Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-b56b65746f2744d287fc01d504d5e8c42022-12-21T19:48:32ZengBMCBMC Musculoskeletal Disorders1471-24742021-05-012211910.1186/s12891-021-04293-7Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS)Takayoshi Matsui0Kazuhiro Hara1Makoto Iwata2Shuntaro Hojo3Nobuyuki Shitara4Yuzo Endo5Hideoki Fukuoka6Masaki Matsui7Hiroshi Kawaguchi8Orthopaedics and Spine Department, Tokyo Neurological CenterMatsui HospitalOrthopaedics and Spine Department, Tokyo Neurological CenterOrthopaedics and Spine Department, Tokyo Neurological CenterOrthopaedics and Spine Department, Tokyo Neurological CenterOrthopaedics and Spine Department, Tokyo Neurological CenterOrthopaedics and Spine Department, Tokyo Neurological CenterMatsui HospitalOrthopaedics and Spine Department, Tokyo Neurological CenterAbstract Background Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) sometimes present with stiffness of the cervical muscles. To investigate the pathophysiology of ME/CFS, this observational study compared patients with versus without recovery from ME/CFS through local modulation of the cervical muscles. Methods Over a period of 11 years, a total of 1226 inpatients with ME/CFS who did not respond to outpatient care were enrolled in this study. All patients received daily cervical muscle physical therapy during hospitalization. Self-rated records documenting the presence or absence of ME/CFS, as well as the representative eight symptoms that frequently accompany it at admission and discharge, were compared. Pupil diameter was also measured to examine autonomic nervous system function involvement. Results The recovery rate of ME/CFS after local therapy was 55.5%, and did not differ significantly by sex, age strata, and hospitalization period. The recovery rates of the eight symptoms were variable (36.6–86.9%); however, those of ME/CFS in the symptom subpopulations were similar (52.3–55.8%). The recovery rates of all symptoms showed strong associations with that of ME/CFS (p < 0.001). The pupil diameter was more constricted in the ME/CFS-recovered patients than in the ME/CFS-unrecovered patients in the total population and the subpopulations stratified by sex, age, and hospitalization period. Conclusions There was a strong association between the recovery of ME/CFS and other related whole-body symptoms. The recovery of ME/CFS may be partly linked to amelioration of the autonomic nervous system in the cervical muscles. Trial registration UMIN000036634 . Registered 1 May 2019 - Retrospectively registered.https://doi.org/10.1186/s12891-021-04293-7Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS)Autonomic nervous systemCervical muscle |
| spellingShingle | Takayoshi Matsui Kazuhiro Hara Makoto Iwata Shuntaro Hojo Nobuyuki Shitara Yuzo Endo Hideoki Fukuoka Masaki Matsui Hiroshi Kawaguchi Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) BMC Musculoskeletal Disorders Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) Autonomic nervous system Cervical muscle |
| title | Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) |
| title_full | Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) |
| title_fullStr | Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) |
| title_full_unstemmed | Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) |
| title_short | Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) |
| title_sort | possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis chronic fatigue syndrome me cfs |
| topic | Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) Autonomic nervous system Cervical muscle |
| url | https://doi.org/10.1186/s12891-021-04293-7 |
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