Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles
The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailab...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1573861 |
| _version_ | 1818849464923717632 |
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| author | Xiao Que Jing Su Pengcheng Guo Zul Kamal Enge Xu Siyu Liu Jieyu Chen Mingfeng Qiu |
| author_facet | Xiao Que Jing Su Pengcheng Guo Zul Kamal Enge Xu Siyu Liu Jieyu Chen Mingfeng Qiu |
| author_sort | Xiao Que |
| collection | DOAJ |
| description | The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailability and short half-life in vivo. Aiming at the above problems, red blood cell membrane-camouflaged TET-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (RPTNs) had been developed. The RPTNs had spherical shell-core double layer structure with average particle size of 164.1 ± 1.65 nm and encapsulation efficiency of 84.1% ± 0.41%. Compared with TET-PLGA nanoparticles (PTNs), the RPTNs reduced RAW 264.7 macrophages’ swallowing by 32% due to its retention of natural membrane proteins. The cumulative drug release of RPTNs was 81.88% within 120 h. And pharmacokinetic study showed that the blood half-life of RPTNs was 19.38 h, which was 2.95 times of free drug. When RPTNs of 2 μg/mL TET were administered in combination with adriamycin (ADR), significant MDR reversal effect was observed in drug-resistant cells MCF-7/ADR. In a word, the RPTNs hold potential to improve its efficacy and broaden its clinical application. |
| first_indexed | 2024-12-19T06:33:40Z |
| format | Article |
| id | doaj.art-b56bd13105724f1a87a2e6eb2c17dce0 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-19T06:33:40Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-b56bd13105724f1a87a2e6eb2c17dce02022-12-21T20:32:18ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126119920710.1080/10717544.2019.15738611573861Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticlesXiao Que0Jing Su1Pengcheng Guo2Zul Kamal3Enge Xu4Siyu Liu5Jieyu ChenMingfeng Qiu6Shanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShaheed Benazir Bhutto UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityThe multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailability and short half-life in vivo. Aiming at the above problems, red blood cell membrane-camouflaged TET-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (RPTNs) had been developed. The RPTNs had spherical shell-core double layer structure with average particle size of 164.1 ± 1.65 nm and encapsulation efficiency of 84.1% ± 0.41%. Compared with TET-PLGA nanoparticles (PTNs), the RPTNs reduced RAW 264.7 macrophages’ swallowing by 32% due to its retention of natural membrane proteins. The cumulative drug release of RPTNs was 81.88% within 120 h. And pharmacokinetic study showed that the blood half-life of RPTNs was 19.38 h, which was 2.95 times of free drug. When RPTNs of 2 μg/mL TET were administered in combination with adriamycin (ADR), significant MDR reversal effect was observed in drug-resistant cells MCF-7/ADR. In a word, the RPTNs hold potential to improve its efficacy and broaden its clinical application.http://dx.doi.org/10.1080/10717544.2019.1573861red blood cell membranetetrandrineplga nanoparticlesmultidrug resistance |
| spellingShingle | Xiao Que Jing Su Pengcheng Guo Zul Kamal Enge Xu Siyu Liu Jieyu Chen Mingfeng Qiu Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles Drug Delivery red blood cell membrane tetrandrine plga nanoparticles multidrug resistance |
| title | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles |
| title_full | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles |
| title_fullStr | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles |
| title_full_unstemmed | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles |
| title_short | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles |
| title_sort | study on preparation characterization and multidrug resistance reversal of red blood cell membrane camouflaged tetrandrine loaded plga nanoparticles |
| topic | red blood cell membrane tetrandrine plga nanoparticles multidrug resistance |
| url | http://dx.doi.org/10.1080/10717544.2019.1573861 |
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