Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy
Microglandular adenosis (MGA) is a lesion that can have an infiltrative pattern, be mass producing and are often challenging to distinguish from a well-differentiated carcinoma. The atypical form, known as atypical microglandular adenosis (AMGA), has increased nuclear irregularity, increased density...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Human Pathology: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221433002030047X |
| _version_ | 1818198690932719616 |
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| author | Hector Chavarria Sean Hacking Cao Jin Nidhi Kataria Florin Glodan Tawfiqul Bhuiya Mansoor Nasim |
| author_facet | Hector Chavarria Sean Hacking Cao Jin Nidhi Kataria Florin Glodan Tawfiqul Bhuiya Mansoor Nasim |
| author_sort | Hector Chavarria |
| collection | DOAJ |
| description | Microglandular adenosis (MGA) is a lesion that can have an infiltrative pattern, be mass producing and are often challenging to distinguish from a well-differentiated carcinoma. The atypical form, known as atypical microglandular adenosis (AMGA), has increased nuclear irregularity, increased density of glands, higher cytologic atypia, prominent nucleoli and numerous apoptotic bodies. Importantly, research has found that microglandular adenosis (MGA) is a non-obligate precursor of triple negative carcinoma of the breast. Most triple negative breast cancers carry a poor prognosis secondary to a lack of therapeutic response. Here we report a case of metaplastic breast carcinoma with chondrosarcomatous differentiation arising from atypical microglandular adenosis. We compare the expression of PD-L1 (SP142), PD-L1 (SP263) and PD-1 (NAT105) as part of the diagnostic and therapeutic workup. The findings demonstrated that this patient could be a candidate for Atezolizumab, an immunotherapeutic associated with clinical response in triple negative breast cancer. |
| first_indexed | 2024-12-12T02:09:53Z |
| format | Article |
| id | doaj.art-b56d7eb7056e4e379c74abf93a73e362 |
| institution | Directory Open Access Journal |
| issn | 2214-3300 |
| language | English |
| last_indexed | 2024-12-12T02:09:53Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology: Case Reports |
| spelling | doaj.art-b56d7eb7056e4e379c74abf93a73e3622022-12-22T00:41:56ZengElsevierHuman Pathology: Case Reports2214-33002020-09-0121200398Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapyHector Chavarria0Sean Hacking1Cao Jin2Nidhi Kataria3Florin Glodan4Tawfiqul Bhuiya5Mansoor Nasim6Corresponding author.; Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United StatesMicroglandular adenosis (MGA) is a lesion that can have an infiltrative pattern, be mass producing and are often challenging to distinguish from a well-differentiated carcinoma. The atypical form, known as atypical microglandular adenosis (AMGA), has increased nuclear irregularity, increased density of glands, higher cytologic atypia, prominent nucleoli and numerous apoptotic bodies. Importantly, research has found that microglandular adenosis (MGA) is a non-obligate precursor of triple negative carcinoma of the breast. Most triple negative breast cancers carry a poor prognosis secondary to a lack of therapeutic response. Here we report a case of metaplastic breast carcinoma with chondrosarcomatous differentiation arising from atypical microglandular adenosis. We compare the expression of PD-L1 (SP142), PD-L1 (SP263) and PD-1 (NAT105) as part of the diagnostic and therapeutic workup. The findings demonstrated that this patient could be a candidate for Atezolizumab, an immunotherapeutic associated with clinical response in triple negative breast cancer.http://www.sciencedirect.com/science/article/pii/S221433002030047XMicrogladular adenosisPD-L1Metaplastic carcinomaTriple negativeBreast cancer |
| spellingShingle | Hector Chavarria Sean Hacking Cao Jin Nidhi Kataria Florin Glodan Tawfiqul Bhuiya Mansoor Nasim Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy Human Pathology: Case Reports Microgladular adenosis PD-L1 Metaplastic carcinoma Triple negative Breast cancer |
| title | Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| title_full | Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| title_fullStr | Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| title_full_unstemmed | Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| title_short | Triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| title_sort | triple negative metaplastic breast carcinoma presenting in the background of atypical microglandular adenosis with candidacy for atezolizumab immunotherapy |
| topic | Microgladular adenosis PD-L1 Metaplastic carcinoma Triple negative Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S221433002030047X |
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