The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant
The using of herbal plants in Indonesia as medicine based on traditional knowledge. One of the herbal plants that believed has medication effect is bay leaves (Syzygiumpolyanthum). Bay leaves contain a flavonoid that can prevent inflammation. The study aims to prove the potency of bay leaves extract...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2019-09-01
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| Series: | Jurnal Teknologi Laboratorium |
| Subjects: | |
| Online Access: | https://www.teknolabjournal.com/index.php/Jtl/article/view/177 |
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| author | Dwi Candra Buana I Ketut Sudiana Jusak Nugraha |
| author_facet | Dwi Candra Buana I Ketut Sudiana Jusak Nugraha |
| author_sort | Dwi Candra Buana |
| collection | DOAJ |
| description | The using of herbal plants in Indonesia as medicine based on traditional knowledge. One of the herbal plants that believed has medication effect is bay leaves (Syzygiumpolyanthum). Bay leaves contain a flavonoid that can prevent inflammation. The study aims to prove the potency of bay leaves extract to prevent the inflammation, which is indicated by decreasing the paw edema thickness in rat induced with Complete Freund's Adjuvant (CFA). This study used 25 animal models of male rat (Rattus norvegicus) strain Wistar that divided into five groups, one group for a normal group (no treatment), one group for positive control which was injected with CFA sub plantar and given treatment with Na CMC and three test groups which is got three different doses of bay leaves extract peroral and the doses were 100 mg/kg BW, 300 mg/kg BW, 400 mg/kg BW, and injected with CFA into the sub plantar. Bay leaves extract was given one hour per oral before injected with CFA. The measurement of paw edema was done at 24 hours after CFA injection. The result of this study showed that bay leaves extract gave the anti-inflammation effect to the rats which were injected with CFA. It is concluded that bay leaves extract containing flavonoids plays a role in inhibit cytokines proinflammatory synthesis. |
| first_indexed | 2024-12-11T07:00:24Z |
| format | Article |
| id | doaj.art-b5704cc614254a438e7ddaed7c097980 |
| institution | Directory Open Access Journal |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| last_indexed | 2024-12-11T07:00:24Z |
| publishDate | 2019-09-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj.art-b5704cc614254a438e7ddaed7c0979802022-12-22T01:16:38ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912019-09-0182646910.29238/teknolabjournal.v8i2.177177The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s AdjuvantDwi Candra Buana0I Ketut Sudiana1Jusak Nugraha2Program Studi Magister Imunologi Sekolah Pascasarjana Universitas AirlanggaDepartment of Clinical Anatomy, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Pathology, Dr. Sutomo General Academic Hospital, Surabaya, IndonesiaThe using of herbal plants in Indonesia as medicine based on traditional knowledge. One of the herbal plants that believed has medication effect is bay leaves (Syzygiumpolyanthum). Bay leaves contain a flavonoid that can prevent inflammation. The study aims to prove the potency of bay leaves extract to prevent the inflammation, which is indicated by decreasing the paw edema thickness in rat induced with Complete Freund's Adjuvant (CFA). This study used 25 animal models of male rat (Rattus norvegicus) strain Wistar that divided into five groups, one group for a normal group (no treatment), one group for positive control which was injected with CFA sub plantar and given treatment with Na CMC and three test groups which is got three different doses of bay leaves extract peroral and the doses were 100 mg/kg BW, 300 mg/kg BW, 400 mg/kg BW, and injected with CFA into the sub plantar. Bay leaves extract was given one hour per oral before injected with CFA. The measurement of paw edema was done at 24 hours after CFA injection. The result of this study showed that bay leaves extract gave the anti-inflammation effect to the rats which were injected with CFA. It is concluded that bay leaves extract containing flavonoids plays a role in inhibit cytokines proinflammatory synthesis.https://www.teknolabjournal.com/index.php/Jtl/article/view/177bay leaves extractantiinflammationcfa |
| spellingShingle | Dwi Candra Buana I Ketut Sudiana Jusak Nugraha The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant Jurnal Teknologi Laboratorium bay leaves extract antiinflammation cfa |
| title | The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant |
| title_full | The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant |
| title_fullStr | The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant |
| title_full_unstemmed | The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant |
| title_short | The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant |
| title_sort | potency of bay leaves extract syzygiumpolyanthum as anti inflammation in rattus norvegicus induced with complete freund s adjuvant |
| topic | bay leaves extract antiinflammation cfa |
| url | https://www.teknolabjournal.com/index.php/Jtl/article/view/177 |
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