IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

Abstract Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by colorectal cancer is...

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Bibliographic Details
Main Authors:	Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan, Zheng Wei
Format:	Article
Language:	English
Published:	BMC 2021-12-01
Series:	Molecular Medicine
Subjects:	Bone metastasis CRC Osteoclast precursors IL-4/IL-4R
Online Access:	https://doi.org/10.1186/s10020-021-00411-2

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