Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands†

Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands†

Abstract New classes of alkylated hetarylpropylguanidines with different functionality and variation in spacer length were synthesized to determine their behavior at the four histamine receptor (H1R, H2R, H3R, H4R) subtypes. Alkylated guanidines with different terminal functional groups and varied b...

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Bibliographic Details
Main Authors: Dr. Steffen Pockes, Dr. David Wifling, Prof. Dr. Armin Buschauer, Prof. Dr. Sigurd Elz
Format: Article
Language:English
Published: Wiley-VCH 2019-03-01
Series:ChemistryOpen
Subjects:
histamine H1-4 receptor
ligand design
receptor subtype selectivity
organ pharmacology
computational chemistry
Online Access:https://doi.org/10.1002/open.201900011

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