Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously report...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13690-5 |
| _version_ | 1818343235263660032 |
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| author | Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K. Hedman Jemma B. Wilk Michael P. Morley Mark D. Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G. Aragam Johan Ärnlöv Joshua D. Backman Mary L. Biggs Heather L. Bloom Jeffrey Brandimarto Michael R. Brown Leonard Buckbinder David J. Carey Daniel I. Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P. Cook Graciela E. Delgado Spiros Denaxas Alexander S. Doney Marcus Dörr Samuel C. Dudley Michael E. Dunn Gunnar Engström Tõnu Esko Stephan B. Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S. Gottdiener Stefan Gross Daníel F. Guðbjartsson Rebecca Gutmann Christopher M. Haggerty Pim van der Harst Craig L. Hyde Erik Ingelsson J. Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E. Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M. Lindgren Barry London Luca A. Lotta Ruth C. Lovering Jian’an Luan Patrik Magnusson Anubha Mahajan Kenneth B. Margulies Winfried März Olle Melander Ify R. Mordi Thomas Morgan Andrew D. Morris Andrew P. Morris Alanna C. Morrison Michael W. Nagle Christopher P. Nelson Alexander Niessner Teemu Niiranen Michelle L. O’Donoghue Anjali T. Owens Colin N. A. Palmer Helen M. Parry Markus Perola Eliana Portilla-Fernandez Bruce M. Psaty Regeneron Genetics Center Kenneth M. Rice Paul M. Ridker Simon P. R. Romaine Jerome I. Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A. Shalaby Diane T. Smelser Nicholas L. Smith Steen Stender David J. Stott Per Svensson Mari-Liis Tammesoo Kent D. Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G. Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A. Voors Xiaosong Wang Nicholas J. Wareham Dawn Waterworth Peter E. Weeke Raul Weiss Kerri L. Wiggins Heming Xing Laura M. Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J. Samani John J. V. McMurray Jian Yang Peter M. Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A. Lubitz Naveed Sattar Michael V. Holmes Thomas P. Cappola Folkert W. Asselbergs Aroon D. Hingorani Karoline Kuchenbaecker Patrick T. Ellinor Chim C. Lang Kari Stefansson J. Gustav Smith Ramachandran S. Vasan Daniel I. Swerdlow R. Thomas Lumbers |
| author_facet | Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K. Hedman Jemma B. Wilk Michael P. Morley Mark D. Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G. Aragam Johan Ärnlöv Joshua D. Backman Mary L. Biggs Heather L. Bloom Jeffrey Brandimarto Michael R. Brown Leonard Buckbinder David J. Carey Daniel I. Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P. Cook Graciela E. Delgado Spiros Denaxas Alexander S. Doney Marcus Dörr Samuel C. Dudley Michael E. Dunn Gunnar Engström Tõnu Esko Stephan B. Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S. Gottdiener Stefan Gross Daníel F. Guðbjartsson Rebecca Gutmann Christopher M. Haggerty Pim van der Harst Craig L. Hyde Erik Ingelsson J. Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E. Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M. Lindgren Barry London Luca A. Lotta Ruth C. Lovering Jian’an Luan Patrik Magnusson Anubha Mahajan Kenneth B. Margulies Winfried März Olle Melander Ify R. Mordi Thomas Morgan Andrew D. Morris Andrew P. Morris Alanna C. Morrison Michael W. Nagle Christopher P. Nelson Alexander Niessner Teemu Niiranen Michelle L. O’Donoghue Anjali T. Owens Colin N. A. Palmer Helen M. Parry Markus Perola Eliana Portilla-Fernandez Bruce M. Psaty Regeneron Genetics Center Kenneth M. Rice Paul M. Ridker Simon P. R. Romaine Jerome I. Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A. Shalaby Diane T. Smelser Nicholas L. Smith Steen Stender David J. Stott Per Svensson Mari-Liis Tammesoo Kent D. Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G. Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A. Voors Xiaosong Wang Nicholas J. Wareham Dawn Waterworth Peter E. Weeke Raul Weiss Kerri L. Wiggins Heming Xing Laura M. Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J. Samani John J. V. McMurray Jian Yang Peter M. Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A. Lubitz Naveed Sattar Michael V. Holmes Thomas P. Cappola Folkert W. Asselbergs Aroon D. Hingorani Karoline Kuchenbaecker Patrick T. Ellinor Chim C. Lang Kari Stefansson J. Gustav Smith Ramachandran S. Vasan Daniel I. Swerdlow R. Thomas Lumbers |
| author_sort | Sonia Shah |
| collection | DOAJ |
| description | Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported. |
| first_indexed | 2024-12-13T16:27:21Z |
| format | Article |
| id | doaj.art-b5721b6147184dcfac6753b6e07e56dd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:27:21Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b5721b6147184dcfac6753b6e07e56dd2022-12-21T23:38:34ZengNature PortfolioNature Communications2041-17232020-01-0111111210.1038/s41467-019-13690-5Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failureSonia Shah0Albert Henry1Carolina Roselli2Honghuang Lin3Garðar Sveinbjörnsson4Ghazaleh Fatemifar5Åsa K. Hedman6Jemma B. Wilk7Michael P. Morley8Mark D. Chaffin9Anna Helgadottir10Niek Verweij11Abbas Dehghan12Peter Almgren13Charlotte Andersson14Krishna G. Aragam15Johan Ärnlöv16Joshua D. Backman17Mary L. Biggs18Heather L. Bloom19Jeffrey Brandimarto20Michael R. Brown21Leonard Buckbinder22David J. Carey23Daniel I. Chasman24Xing Chen25Xu Chen26Jonathan Chung27William Chutkow28James P. Cook29Graciela E. Delgado30Spiros Denaxas31Alexander S. Doney32Marcus Dörr33Samuel C. Dudley34Michael E. Dunn35Gunnar Engström36Tõnu Esko37Stephan B. Felix38Chris Finan39Ian Ford40Mohsen Ghanbari41Sahar Ghasemi42Vilmantas Giedraitis43Franco Giulianini44John S. Gottdiener45Stefan Gross46Daníel F. Guðbjartsson47Rebecca Gutmann48Christopher M. Haggerty49Pim van der Harst50Craig L. Hyde51Erik Ingelsson52J. Wouter Jukema53Maryam Kavousi54Kay-Tee Khaw55Marcus E. Kleber56Lars Køber57Andrea Koekemoer58Claudia Langenberg59Lars Lind60Cecilia M. Lindgren61Barry London62Luca A. Lotta63Ruth C. Lovering64Jian’an Luan65Patrik Magnusson66Anubha Mahajan67Kenneth B. Margulies68Winfried März69Olle Melander70Ify R. Mordi71Thomas Morgan72Andrew D. Morris73Andrew P. Morris74Alanna C. Morrison75Michael W. Nagle76Christopher P. Nelson77Alexander Niessner78Teemu Niiranen79Michelle L. O’Donoghue80Anjali T. Owens81Colin N. A. Palmer82Helen M. Parry83Markus Perola84Eliana Portilla-Fernandez85Bruce M. Psaty86Regeneron Genetics CenterKenneth M. Rice87Paul M. Ridker88Simon P. R. Romaine89Jerome I. Rotter90Perttu Salo91Veikko Salomaa92Jessica van Setten93Alaa A. Shalaby94Diane T. Smelser95Nicholas L. Smith96Steen Stender97David J. Stott98Per Svensson99Mari-Liis Tammesoo100Kent D. Taylor101Maris Teder-Laving102Alexander Teumer103Guðmundur Thorgeirsson104Unnur Thorsteinsdottir105Christian Torp-Pedersen106Stella Trompet107Benoit Tyl108Andre G. Uitterlinden109Abirami Veluchamy110Uwe Völker111Adriaan A. Voors112Xiaosong Wang113Nicholas J. Wareham114Dawn Waterworth115Peter E. Weeke116Raul Weiss117Kerri L. Wiggins118Heming Xing119Laura M. Yerges-Armstrong120Bing Yu121Faiez Zannad122Jing Hua Zhao123Harry Hemingway124Nilesh J. Samani125John J. V. McMurray126Jian Yang127Peter M. Visscher128Christopher Newton-Cheh129Anders Malarstig130Hilma Holm131Steven A. Lubitz132Naveed Sattar133Michael V. Holmes134Thomas P. Cappola135Folkert W. Asselbergs136Aroon D. Hingorani137Karoline Kuchenbaecker138Patrick T. Ellinor139Chim C. Lang140Kari Stefansson141J. Gustav Smith142Ramachandran S. Vasan143Daniel I. Swerdlow144R. Thomas Lumbers145Institute for Molecular Bioscience, The University of QueenslandInstitute of Cardiovascular Science, University College LondonProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardSection of Computational Biomedicine, Department of Medicine, Boston University School of MedicinedeCODE genetics/Amgen Inc.British Heart Foundation Research Accelerator, University College LondonCardiovascular Medicine unit, Department of Medicine Solna, Karolinska InstitutePfizer Worldwide Research & DevelopmentPenn Cardiovascular Institute, Perelman School of Medicine, University of PennsylvaniaProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvarddeCODE genetics/Amgen Inc.Program in Medical and Population Genetics, The Broad Institute of MIT and HarvardDepartment of Epidemiology and Biostatistics, Imperial College London, St Mary’s CampusDepartment of Clinical Sciences, Lund UniversityNational Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart StudyProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardDepartment of Neurobiology, Care Sciences and Society/ Section of Family Medicine and Primary Care, Karolinska InstitutetRegeneron Genetics CenterDepartment of Biostatistics, University of WashingtonDivision of Cardiology, Department of Medicine, Emory University Medical CenterPenn Cardiovascular Institute, Perelman School of Medicine, University of PennsylvaniaDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public HealthPfizer Worldwide Research & DevelopmentDepartment of Molecular and Functional Genomics, GeisingerDivision of Preventive Medicine, Brigham and Women’s HospitalPfizer Worldwide Research & DevelopmentDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetRegeneron Genetics CenterNovartis Institutes for Biomedical ResearchDepartment of Biostatistics, University of LiverpoolVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of HeidelbergBritish Heart Foundation Research Accelerator, University College LondonDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchoolDepartment of Internal Medicine B, University Medicine GreifswaldCardiovascular Division, Department of Medicine, University of MinnesotaRegeneron Pharmaceuticals, Cardiovascular ResearchDepartment of Clinical Sciences, Lund UniversityProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardDepartment of Internal Medicine B, University Medicine GreifswaldInstitute of Cardiovascular Science, University College LondonRobertson Center for Biostatistics, University of GlasgowDepartment of Epidemiology, Erasmus University Medical CenterDZHK (German Center for Cardiovascular Research), partner site GreifswaldDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala UniversityDivision of Preventive Medicine, Brigham and Women’s HospitalDepartment of Medicine, Division of Cardiology, University of Maryland School of MedicineDepartment of Internal Medicine B, University Medicine GreifswalddeCODE genetics/Amgen Inc.Division of Cardiovascular Medicine, University of Iowa Carver College of MedicineDepartment of Molecular and Functional Genomics, GeisingerDepartment of Cardiology, University Medical Center Groningen, University of GroningenPfizer Worldwide Research & DevelopmentDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of MedicineDepartment of Cardiology, Leiden University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Public Health and Primary Care, University of CambridgeVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of HeidelbergDepartment of Cardiology, Copenhagen University Hospital RigshospitaletDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield HospitalMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineDepartment of Medical Sciences, Uppsala UniversityProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardDivision of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of IowaMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineInstitute of Cardiovascular Science, University College LondonMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetWellcome Trust Centre for Human Genetics, University of OxfordPenn Cardiovascular Institute, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, University of LiverpoolDepartment of Internal Medicine, Clinical Sciences, Lund University and Skåne University HospitalDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchoolNovartis Institutes for Biomedical ResearchUsher Institute of Population Health Sciences and Informatics, University of EdinburghDepartment of Biostatistics, University of LiverpoolDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public HealthPfizer Worldwide Research & DevelopmentDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield HospitalDepartment of Internal Medicine II, Division of Cardiology, Medical University of ViennaNational Institute for Health and WelfareTIMI Study Group, Cardiovascular Division, Brigham and Women’s HospitalPenn Cardiovascular Institute, Perelman School of Medicine, University of PennsylvaniaDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchoolDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchoolNational Institute for Health and WelfareDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Medicine, Epidemiology, and Health Services, University of WashingtonDepartment of Biostatistics, University of WashingtonDivision of Preventive Medicine, Brigham and Women’s HospitalDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield HospitalThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterNational Institute for Health and WelfareNational Institute for Health and WelfareDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of UtrechtDivision of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCSDepartment of Molecular and Functional Genomics, GeisingerKaiser Permanente Washington Health Research Institute, Kaiser Permanente WashingtonDepartment of Clinical Biochemistry, Copenhagen University Hospital, Herlev and GentofteInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Clinical Science and Education, Södersjukhuset, Karolinska InstitutetEstonian Genome Center, Institute of Genomics, University of TartuInstitute for Translational Genomics and Population Sciences, LABiomed and Departments of Pediatrics at Harbor-UCLA Medical CenterEstonian Genome Center, Institute of Genomics, University of TartuDZHK (German Center for Cardiovascular Research), partner site GreifswalddeCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.Department of Epidemiology and Biostatistics, Aalborg University HospitalDepartment of Cardiology, Leiden University Medical CenterTranslational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, 50 rue CarnotDepartment of Epidemiology, Erasmus University Medical CenterDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchoolDZHK (German Center for Cardiovascular Research), partner site GreifswaldSection of Computational Biomedicine, Department of Medicine, Boston University School of MedicineNovartis Institutes for Biomedical ResearchMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineHuman Genetics, GlaxoSmithKlineDepartment of Cardiology, Copenhagen University Hospital RigshospitaletDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical CenterDepartment of Medicine, University of WashingtonNovartis Institutes for Biomedical ResearchHuman Genetics, GlaxoSmithKlineDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public HealthUniversité de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des VaisseauxMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineBritish Heart Foundation Research Accelerator, University College LondonDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield HospitalBHF Cardiovascular Research Centre, University of GlasgowInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardCardiovascular Medicine unit, Department of Medicine Solna, Karolinska InstitutedeCODE genetics/Amgen Inc.Program in Medical and Population Genetics, The Broad Institute of MIT and HarvardBHF Cardiovascular Research Centre, University of GlasgowMedical Research Council Population Health Research Unit at the University of OxfordPenn Cardiovascular Institute, Perelman School of Medicine, University of PennsylvaniaInstitute of Cardiovascular Science, University College LondonInstitute of Cardiovascular Science, University College LondonDivision of Psychiatry, University College of LondonProgram in Medical and Population Genetics, The Broad Institute of MIT and HarvardDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical SchooldeCODE genetics/Amgen Inc.Program in Medical and Population Genetics, The Broad Institute of MIT and HarvardNational Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart StudyInstitute of Cardiovascular Science, University College LondonBritish Heart Foundation Research Accelerator, University College LondonHeart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.https://doi.org/10.1038/s41467-019-13690-5 |
| spellingShingle | Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K. Hedman Jemma B. Wilk Michael P. Morley Mark D. Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G. Aragam Johan Ärnlöv Joshua D. Backman Mary L. Biggs Heather L. Bloom Jeffrey Brandimarto Michael R. Brown Leonard Buckbinder David J. Carey Daniel I. Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P. Cook Graciela E. Delgado Spiros Denaxas Alexander S. Doney Marcus Dörr Samuel C. Dudley Michael E. Dunn Gunnar Engström Tõnu Esko Stephan B. Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S. Gottdiener Stefan Gross Daníel F. Guðbjartsson Rebecca Gutmann Christopher M. Haggerty Pim van der Harst Craig L. Hyde Erik Ingelsson J. Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E. Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M. Lindgren Barry London Luca A. Lotta Ruth C. Lovering Jian’an Luan Patrik Magnusson Anubha Mahajan Kenneth B. Margulies Winfried März Olle Melander Ify R. Mordi Thomas Morgan Andrew D. Morris Andrew P. Morris Alanna C. Morrison Michael W. Nagle Christopher P. Nelson Alexander Niessner Teemu Niiranen Michelle L. O’Donoghue Anjali T. Owens Colin N. A. Palmer Helen M. Parry Markus Perola Eliana Portilla-Fernandez Bruce M. Psaty Regeneron Genetics Center Kenneth M. Rice Paul M. Ridker Simon P. R. Romaine Jerome I. Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A. Shalaby Diane T. Smelser Nicholas L. Smith Steen Stender David J. Stott Per Svensson Mari-Liis Tammesoo Kent D. Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G. Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A. Voors Xiaosong Wang Nicholas J. Wareham Dawn Waterworth Peter E. Weeke Raul Weiss Kerri L. Wiggins Heming Xing Laura M. Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J. Samani John J. V. McMurray Jian Yang Peter M. Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A. Lubitz Naveed Sattar Michael V. Holmes Thomas P. Cappola Folkert W. Asselbergs Aroon D. Hingorani Karoline Kuchenbaecker Patrick T. Ellinor Chim C. Lang Kari Stefansson J. Gustav Smith Ramachandran S. Vasan Daniel I. Swerdlow R. Thomas Lumbers Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure Nature Communications |
| title | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| title_full | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| title_fullStr | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| title_full_unstemmed | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| title_short | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| title_sort | genome wide association and mendelian randomisation analysis provide insights into the pathogenesis of heart failure |
| url | https://doi.org/10.1038/s41467-019-13690-5 |
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genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jiananluan genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT patrikmagnusson genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT anubhamahajan genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT kennethbmargulies genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT winfriedmarz genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT ollemelander genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT ifyrmordi genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT thomasmorgan genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT andrewdmorris genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT andrewpmorris genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT alannacmorrison genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT michaelwnagle genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT christopherpnelson genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT alexanderniessner genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT teemuniiranen genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT michellelodonoghue genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT anjalitowens genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT colinnapalmer genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT helenmparry genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT markusperola genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT elianaportillafernandez genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT brucempsaty genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT regenerongeneticscenter genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT kennethmrice genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT paulmridker genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT simonprromaine genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jeromeirotter genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT perttusalo genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT veikkosalomaa genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jessicavansetten genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT alaaashalaby genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT dianetsmelser genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT nicholaslsmith genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT steenstender genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT davidjstott genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT persvensson genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT mariliistammesoo genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT kentdtaylor genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT maristederlaving genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT alexanderteumer genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT guðmundurthorgeirsson genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT unnurthorsteinsdottir genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT christiantorppedersen genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT stellatrompet genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT benoittyl genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT andreguitterlinden genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT abiramiveluchamy genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT uwevolker genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT adriaanavoors genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT xiaosongwang genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT nicholasjwareham genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT dawnwaterworth genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT petereweeke genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT raulweiss genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT kerrilwiggins genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT hemingxing genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT lauramyergesarmstrong genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT bingyu genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT faiezzannad genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jinghuazhao genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT harryhemingway genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT nileshjsamani genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT johnjvmcmurray genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jianyang genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT petermvisscher genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT christophernewtoncheh genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT andersmalarstig genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT hilmaholm genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT stevenalubitz genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT naveedsattar genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT michaelvholmes genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT thomaspcappola genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT folkertwasselbergs genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT aroondhingorani genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT karolinekuchenbaecker genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT patricktellinor genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT chimclang genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT karistefansson genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT jgustavsmith genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT ramachandransvasan genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT danieliswerdlow genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure AT rthomaslumbers genomewideassociationandmendelianrandomisationanalysisprovideinsightsintothepathogenesisofheartfailure |