Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research
Adropin is a unique hormone encoded by the energy homeostasis-associated (<i>Enho</i>) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade aft...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/3/549 |
| _version_ | 1818806532018536448 |
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| author | Mariami Jasaszwili Maria Billert Mathias Z. Strowski Krzysztof W. Nowak Marek Skrzypski |
| author_facet | Mariami Jasaszwili Maria Billert Mathias Z. Strowski Krzysztof W. Nowak Marek Skrzypski |
| author_sort | Mariami Jasaszwili |
| collection | DOAJ |
| description | Adropin is a unique hormone encoded by the energy homeostasis-associated (<i>Enho</i>) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating <i>Enho</i> as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer. |
| first_indexed | 2024-12-18T19:11:16Z |
| format | Article |
| id | doaj.art-b574b10d7c86415ea65d7cb1c3a340f6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T19:11:16Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b574b10d7c86415ea65d7cb1c3a340f62022-12-21T20:56:15ZengMDPI AGMolecules1420-30492020-01-0125354910.3390/molecules25030549molecules25030549Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of ResearchMariami Jasaszwili0Maria Billert1Mathias Z. Strowski2Krzysztof W. Nowak3Marek Skrzypski4Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, PolandDepartment of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, PolandDepartment of Hepatology and Gastroenterology, Charité-University Medicine Berlin, D-13353 Berlin, GermanyDepartment of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, PolandDepartment of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, PolandAdropin is a unique hormone encoded by the energy homeostasis-associated (<i>Enho</i>) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating <i>Enho</i> as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer.https://www.mdpi.com/1420-3049/25/3/549adropin<i>enho</i>adipositymetabolismtype 2 diabeteslivercancercardiovascular system |
| spellingShingle | Mariami Jasaszwili Maria Billert Mathias Z. Strowski Krzysztof W. Nowak Marek Skrzypski Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research Molecules adropin <i>enho</i> adiposity metabolism type 2 diabetes liver cancer cardiovascular system |
| title | Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research |
| title_full | Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research |
| title_fullStr | Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research |
| title_full_unstemmed | Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research |
| title_short | Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research |
| title_sort | adropin as a fat burning hormone with multiple functions review of a decade of research |
| topic | adropin <i>enho</i> adiposity metabolism type 2 diabetes liver cancer cardiovascular system |
| url | https://www.mdpi.com/1420-3049/25/3/549 |
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