Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis

Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis

The epithelial-to-mesenchymal transition (EMT) is a highly conserved morphogenetic program essential for embryogenesis, regeneration and cancer metastasis. In cancer cells, EMT also triggers cellular reprogramming and chemoresistance, which underlie disease relapse and decreased survival. Hence, ide...

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Bibliographic Details
Main Authors: Laura Jimenez, Jindong Wang, Monique A. Morrison, Clifford Whatcott, Katherine K. Soh, Steven Warner, David Bearss, Cicely A. Jette, Rodney A. Stewart
Format: Article
Language:English
Published: The Company of Biologists 2016-04-01
Series:Disease Models & Mechanisms
Subjects:
Drug screen
EMT
Epithelial mesenchymal
Neural crest
Retinoic acid
Zebrafish
Online Access:http://dmm.biologists.org/content/9/4/389

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