Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip
Understanding the mechanism of particle transport and sedimentation in pulmonary alveolus is important for deciphering the causes of respiratory diseases and helping the development of drug delivery. In this study, taking advantage of the microfluidic technique, an experimental platform was develope...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/3/485 |
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| author | Wei Zhang Jun Dong Huimin Lv Weitao Bai Hongzhou Lu Bernd R. Noack Yonggang Zhu Yue Yang |
| author_facet | Wei Zhang Jun Dong Huimin Lv Weitao Bai Hongzhou Lu Bernd R. Noack Yonggang Zhu Yue Yang |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Understanding the mechanism of particle transport and sedimentation in pulmonary alveolus is important for deciphering the causes of respiratory diseases and helping the development of drug delivery. In this study, taking advantage of the microfluidic technique, an experimental platform was developed to study particle behavior in a rhythmically expanding alveolar chip for a sufficient number of cycles. The alveolar flow patterns at different generations were measured for two cases with the gravity direction parallel or vertical to the alveolar duct. Affected by both the vortex flow inside the alveoli and the shear flow in the duct simultaneously, it was observed that particles inside the alveoli either escaped from the inlet of the alveolar duct or stayed in the alveoli, revealing the irreversibility of particle transport in the alveoli. At the earlier acinar generations, particles were inclined to deposit on the distal alveolar wall. The settling rates of particles of different sizes in the alveoli were also compared. This study provides valuable data for understanding particle transport and sedimentation in the alveoli. |
| first_indexed | 2024-03-09T13:16:44Z |
| format | Article |
| id | doaj.art-b5775058afd24d25be8d422c795c0d1b |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T13:16:44Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-b5775058afd24d25be8d422c795c0d1b2023-11-30T21:34:50ZengMDPI AGMicromachines2072-666X2022-03-0113348510.3390/mi13030485Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar ChipWei Zhang0Jun Dong1Huimin Lv2Weitao Bai3Hongzhou Lu4Bernd R. Noack5Yonggang Zhu6Yue Yang7School of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaNational Clinical Research Centre for Infectious Diseases, The Third People’s Hospital of Shenzhen (The Second Affiliated Hospital of Southern University of Science and Technology), Shenzhen 518112, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, ChinaUnderstanding the mechanism of particle transport and sedimentation in pulmonary alveolus is important for deciphering the causes of respiratory diseases and helping the development of drug delivery. In this study, taking advantage of the microfluidic technique, an experimental platform was developed to study particle behavior in a rhythmically expanding alveolar chip for a sufficient number of cycles. The alveolar flow patterns at different generations were measured for two cases with the gravity direction parallel or vertical to the alveolar duct. Affected by both the vortex flow inside the alveoli and the shear flow in the duct simultaneously, it was observed that particles inside the alveoli either escaped from the inlet of the alveolar duct or stayed in the alveoli, revealing the irreversibility of particle transport in the alveoli. At the earlier acinar generations, particles were inclined to deposit on the distal alveolar wall. The settling rates of particles of different sizes in the alveoli were also compared. This study provides valuable data for understanding particle transport and sedimentation in the alveoli.https://www.mdpi.com/2072-666X/13/3/485alveolar chipparticle trackingmicrofluidicsdynamical similarityparticle deposition |
| spellingShingle | Wei Zhang Jun Dong Huimin Lv Weitao Bai Hongzhou Lu Bernd R. Noack Yonggang Zhu Yue Yang Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip Micromachines alveolar chip particle tracking microfluidics dynamical similarity particle deposition |
| title | Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip |
| title_full | Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip |
| title_fullStr | Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip |
| title_full_unstemmed | Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip |
| title_short | Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip |
| title_sort | microparticle transport and sedimentation in a rhythmically expanding alveolar chip |
| topic | alveolar chip particle tracking microfluidics dynamical similarity particle deposition |
| url | https://www.mdpi.com/2072-666X/13/3/485 |
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