Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation. Although Panx1 and P2X7R are implicated in the process of inflammation and cell death, few...

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Bibliographic Details
Main Authors: Erica F. Diezmos, Irit Markus, D. S. Perera, Steven Gan, Li Zhang, Shaun L. Sandow, Paul P. Bertrand, Lu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
pannexin-1
P2X7 receptor
colonic inflammation
human colitis
tissue explants
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00865/full

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