SITE-SPECIFIC LABELING OF A PROTEIN LYSINE RESIDUE BY NOVEL KINETIC LABELING COMBINATORIAL LIBRARIES

SITE-SPECIFIC LABELING OF A PROTEIN LYSINE RESIDUE BY NOVEL KINETIC LABELING COMBINATORIAL LIBRARIES

The first example of a kinetic labeling library designed to enable the discovery of affinity labels is presented. Each library component (1) consists of a variable peptidyl component linked to a biotinyl moiety by a 4-mercaptobenzoyl linker in thioester format. We demonstrate that an affinity label...

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Bibliographic Details
Main Authors: Allen Krantz, Arthur M Hanel, Ivona Strug, Andrzej Wilczynski, Jeremy J Wolff, Wolin Huang, Linda H Huang, Tina Settineri, Darren L Holmes, Margaret C Hardy, Dominique P Bridon
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Site-specific protein modification
Kinetic labeling libraries
Affinity labels
Lysine labeling
Combinatorial libraries
Peptide libraries
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600015

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