Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-07387-2 |
| _version_ | 1818754278295076864 |
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| author | Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska |
| author_facet | Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska |
| author_sort | Stefan G. Pierzynowski |
| collection | DOAJ |
| description | Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes. |
| first_indexed | 2024-12-18T05:20:43Z |
| format | Article |
| id | doaj.art-b5789c371c734b84ba7460ec21e6bd41 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:20:43Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b5789c371c734b84ba7460ec21e6bd412022-12-21T21:19:40ZengNature PortfolioScientific Reports2045-23222017-08-01711910.1038/s41598-017-07387-2Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig modelStefan G. Pierzynowski0Kateryna Goncharova1Peter C. Gregory2Björn Weström3Sergiy E. Podpryatov4Sergii S. Podpriatov5Jarosław Woliński6Hlib Repich7Nils Wierup8Liudmyla Lozinska9Department of Biology, Lund UniversityDepartment of Biology, Lund UniversityAnaraDepartment of Biology, Lund UniversityAnaraAnaraDepartment of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of SciencesDepartment of Biology, Lund UniversityDepartment of Clinical Sciences, Lund University Diabetes CentreDepartment of Biology, Lund UniversityAbstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.https://doi.org/10.1038/s41598-017-07387-2 |
| spellingShingle | Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model Scientific Reports |
| title | Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| title_full | Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| title_fullStr | Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| title_full_unstemmed | Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| title_short | Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| title_sort | experiments suggesting extra digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model |
| url | https://doi.org/10.1038/s41598-017-07387-2 |
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