The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Hereditary Cancer in Clinical Practice |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13053-017-0076-7 |
| _version_ | 1818973221539545088 |
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| author | Agnieszka Strumidło Sylwia Skiba Rodney J. Scott Jan Lubiński |
| author_facet | Agnieszka Strumidło Sylwia Skiba Rodney J. Scott Jan Lubiński |
| author_sort | Agnieszka Strumidło |
| collection | DOAJ |
| description | Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations. |
| first_indexed | 2024-12-20T15:20:43Z |
| format | Article |
| id | doaj.art-b57bea7c78f84c8386330cc9d018363b |
| institution | Directory Open Access Journal |
| issn | 1897-4287 |
| language | English |
| last_indexed | 2024-12-20T15:20:43Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditary Cancer in Clinical Practice |
| spelling | doaj.art-b57bea7c78f84c8386330cc9d018363b2022-12-21T19:36:03ZengBMCHereditary Cancer in Clinical Practice1897-42872017-09-011511510.1186/s13053-017-0076-7The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutationAgnieszka Strumidło0Sylwia Skiba1Rodney J. Scott2Jan Lubiński3Pomeranian University of MedicinePomeranian University of MedicineThe University of Newcastle and Hunter Medical Research InstituteDepartment of Genetics and Pathology, Pomeranian University of MedicineAbstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations.http://link.springer.com/article/10.1186/s13053-017-0076-7Breast cancerOvarian cancerBRCA1microRNATreatment |
| spellingShingle | Agnieszka Strumidło Sylwia Skiba Rodney J. Scott Jan Lubiński The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation Hereditary Cancer in Clinical Practice Breast cancer Ovarian cancer BRCA1 microRNA Treatment |
| title | The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation |
| title_full | The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation |
| title_fullStr | The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation |
| title_full_unstemmed | The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation |
| title_short | The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation |
| title_sort | potential role of mirnas in therapy of breast and ovarian cancers associated with brca1 mutation |
| topic | Breast cancer Ovarian cancer BRCA1 microRNA Treatment |
| url | http://link.springer.com/article/10.1186/s13053-017-0076-7 |
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