Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis
Abstract Background The mechanism of humoral immunity to Takayasu arteritis (TAK) is not clear. In our study, we aimed to investigate the correlation between immunoglobulins and disease activity and the relationship between immunoglobulins and the prognosis of TAK patients. Methods One hundred ninet...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-023-03016-8 |
| _version_ | 1797863965890445312 |
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| author | Yanqiu Guo Juan Du Taotao Li Na Gao Shiyu Yang Yaxin Zhang Lili Pan |
| author_facet | Yanqiu Guo Juan Du Taotao Li Na Gao Shiyu Yang Yaxin Zhang Lili Pan |
| author_sort | Yanqiu Guo |
| collection | DOAJ |
| description | Abstract Background The mechanism of humoral immunity to Takayasu arteritis (TAK) is not clear. In our study, we aimed to investigate the correlation between immunoglobulins and disease activity and the relationship between immunoglobulins and the prognosis of TAK patients. Methods One hundred ninety TAK patients divided into two groups according to whether they had elevated immunoglobulins or not. We compared the demographic data and the clinical data between the two groups. Pearson correlation was used to analyze the relationship between immunoglobulin and disease activity, as well as the relationship between their changes. Immunohistochemical staining was used to compare the expression of humoral immune cells in TAK and atherosclerotic patients. One hundred twenty TAK patients who achieved remission within 3 months after discharge were followed up for 1 year. Logistic regression was used to explore the relationship between elevated immunoglobulins and recurrence. Results Disease activity and inflammatory factors were significantly higher in the group with elevated immunoglobulins than in the normal group [NIH (3.0 vs. 2.0, P = 0.001), ITAS-A (9.0 vs. 7.0, P = 0.006)]. Compared with atherosclerotic patients, CD138 + plasma cells were significantly increased in the aortic wall of patients with TAK (P = 0.021). Changes in IgG correlated well with CRP and ESR [CRP (r = 0.40, P = 0.027), ESR (r = 0.64, P < 0.001)]. For patients with TAK in remission, elevated immunoglobulins was associated with 1-year recurrence [OR95%, CI: 2.37 (1.03, 5.47), P = 0.042]. Conclusions Immunoglobulins is of clinical value in evaluating disease activity in TAK patients. Moreover, the dynamic changes of IgG were correlated with the changes in inflammatory indicators in TAK patients. |
| first_indexed | 2024-04-09T22:44:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-09T22:44:05Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-b57d2087c0354cb8a7ad1cb18fac87d72023-03-22T11:58:43ZengBMCArthritis Research & Therapy1478-63622023-03-012511910.1186/s13075-023-03016-8Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritisYanqiu Guo0Juan Du1Taotao Li2Na Gao3Shiyu Yang4Yaxin Zhang5Lili Pan6Department of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Background The mechanism of humoral immunity to Takayasu arteritis (TAK) is not clear. In our study, we aimed to investigate the correlation between immunoglobulins and disease activity and the relationship between immunoglobulins and the prognosis of TAK patients. Methods One hundred ninety TAK patients divided into two groups according to whether they had elevated immunoglobulins or not. We compared the demographic data and the clinical data between the two groups. Pearson correlation was used to analyze the relationship between immunoglobulin and disease activity, as well as the relationship between their changes. Immunohistochemical staining was used to compare the expression of humoral immune cells in TAK and atherosclerotic patients. One hundred twenty TAK patients who achieved remission within 3 months after discharge were followed up for 1 year. Logistic regression was used to explore the relationship between elevated immunoglobulins and recurrence. Results Disease activity and inflammatory factors were significantly higher in the group with elevated immunoglobulins than in the normal group [NIH (3.0 vs. 2.0, P = 0.001), ITAS-A (9.0 vs. 7.0, P = 0.006)]. Compared with atherosclerotic patients, CD138 + plasma cells were significantly increased in the aortic wall of patients with TAK (P = 0.021). Changes in IgG correlated well with CRP and ESR [CRP (r = 0.40, P = 0.027), ESR (r = 0.64, P < 0.001)]. For patients with TAK in remission, elevated immunoglobulins was associated with 1-year recurrence [OR95%, CI: 2.37 (1.03, 5.47), P = 0.042]. Conclusions Immunoglobulins is of clinical value in evaluating disease activity in TAK patients. Moreover, the dynamic changes of IgG were correlated with the changes in inflammatory indicators in TAK patients.https://doi.org/10.1186/s13075-023-03016-8Takayasu arteritisImmunoglobulinDisease activityRecurrence |
| spellingShingle | Yanqiu Guo Juan Du Taotao Li Na Gao Shiyu Yang Yaxin Zhang Lili Pan Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis Arthritis Research & Therapy Takayasu arteritis Immunoglobulin Disease activity Recurrence |
| title | Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis |
| title_full | Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis |
| title_fullStr | Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis |
| title_full_unstemmed | Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis |
| title_short | Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis |
| title_sort | elevated serum immunoglobulin level predicts high risk of 1 year recurrence in patients with takayasu arteritis |
| topic | Takayasu arteritis Immunoglobulin Disease activity Recurrence |
| url | https://doi.org/10.1186/s13075-023-03016-8 |
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