Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population
This study employs fMRI to examine the neural substrates of response to cognitive training in healthy old adults. Twenty Japanese healthy elders participated in a 4-week program and practiced a verbal articulation task on a daily basis. Functional connectivity analysis revealed that in comparison to...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.786853/full |
| _version_ | 1818906870606200832 |
|---|---|
| author | Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Tzu-Yu Liu Tzu-Yu Liu Chih-Hsuan Liu Chih-Hsuan Liu Shumei Murakami Toshiharu Nakai Toshiharu Nakai |
| author_facet | Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Tzu-Yu Liu Tzu-Yu Liu Chih-Hsuan Liu Chih-Hsuan Liu Shumei Murakami Toshiharu Nakai Toshiharu Nakai |
| author_sort | Fan-Pei Gloria Yang |
| collection | DOAJ |
| description | This study employs fMRI to examine the neural substrates of response to cognitive training in healthy old adults. Twenty Japanese healthy elders participated in a 4-week program and practiced a verbal articulation task on a daily basis. Functional connectivity analysis revealed that in comparison to age- and education-matched controls, elders who received the cognitive training demonstrated increased connectivity in the frontotemporal regions related with language and memory functions and showed significant correlations between the behavioral change in a linguistic task and connectivity in regions for goal-oriented persistence and lexical processing. The increased hippocampal connectivity was consistent with previous research showing efficacious memory improvement and change in hippocampal functioning. Moreover, the increased intra-network connectivity following cognitive training suggested an improved neural differentiation, in contrast to the inter-network activation pattern typical in the aging brain. This research not only validates the relationship of functional change in the frontal and temporal lobes to age-associated cognitive decline but also shows promise in turning neural change toward the right direction by cognitive training. |
| first_indexed | 2024-12-19T21:46:06Z |
| format | Article |
| id | doaj.art-b57ea99ef9bf4df09d828673c781bb83 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-19T21:46:06Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-b57ea99ef9bf4df09d828673c781bb832022-12-21T20:04:32ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-03-011610.3389/fnhum.2022.786853786853Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly PopulationFan-Pei Gloria Yang0Fan-Pei Gloria Yang1Fan-Pei Gloria Yang2Tzu-Yu Liu3Tzu-Yu Liu4Chih-Hsuan Liu5Chih-Hsuan Liu6Shumei Murakami7Toshiharu Nakai8Toshiharu Nakai9Department of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanCenter for Cognition and Mind Sciences, National Tsing Hua University, Hsinchu, TaiwanDepartment of Radiology, Graduate School of Dentistry, Osaka University, Suita, JapanDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanCenter for Cognition and Mind Sciences, National Tsing Hua University, Hsinchu, TaiwanDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanCenter for Cognition and Mind Sciences, National Tsing Hua University, Hsinchu, TaiwanDepartment of Radiology, Graduate School of Dentistry, Osaka University, Suita, JapanDepartment of Radiology, Graduate School of Dentistry, Osaka University, Suita, JapanInstitute of NeuroImaging and Informatics, Obu, JapanThis study employs fMRI to examine the neural substrates of response to cognitive training in healthy old adults. Twenty Japanese healthy elders participated in a 4-week program and practiced a verbal articulation task on a daily basis. Functional connectivity analysis revealed that in comparison to age- and education-matched controls, elders who received the cognitive training demonstrated increased connectivity in the frontotemporal regions related with language and memory functions and showed significant correlations between the behavioral change in a linguistic task and connectivity in regions for goal-oriented persistence and lexical processing. The increased hippocampal connectivity was consistent with previous research showing efficacious memory improvement and change in hippocampal functioning. Moreover, the increased intra-network connectivity following cognitive training suggested an improved neural differentiation, in contrast to the inter-network activation pattern typical in the aging brain. This research not only validates the relationship of functional change in the frontal and temporal lobes to age-associated cognitive decline but also shows promise in turning neural change toward the right direction by cognitive training.https://www.frontiersin.org/articles/10.3389/fnhum.2022.786853/fullfMRIagingconnectivityplasticityhippocampusrsfMRI = resting state fMRI |
| spellingShingle | Fan-Pei Gloria Yang Fan-Pei Gloria Yang Fan-Pei Gloria Yang Tzu-Yu Liu Tzu-Yu Liu Chih-Hsuan Liu Chih-Hsuan Liu Shumei Murakami Toshiharu Nakai Toshiharu Nakai Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population Frontiers in Human Neuroscience fMRI aging connectivity plasticity hippocampus rsfMRI = resting state fMRI |
| title | Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population |
| title_full | Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population |
| title_fullStr | Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population |
| title_full_unstemmed | Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population |
| title_short | Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population |
| title_sort | verbal training induces enhanced functional connectivity in japanese healthy elderly population |
| topic | fMRI aging connectivity plasticity hippocampus rsfMRI = resting state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.786853/full |
| work_keys_str_mv | AT fanpeigloriayang verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT fanpeigloriayang verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT fanpeigloriayang verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT tzuyuliu verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT tzuyuliu verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT chihhsuanliu verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT chihhsuanliu verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT shumeimurakami verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT toshiharunakai verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation AT toshiharunakai verbaltraininginducesenhancedfunctionalconnectivityinjapanesehealthyelderlypopulation |