Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects

Abstract Background Curcumin and piperine are major bioactive compounds of Curcuma longa and Piper nigrum, widely consumed as spices and flock medicine. The combinational use of these plants is a common practice in Southeast Asia. Synergism between curcumin and piperine has been found in several ani...

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Bibliographic Details
Main Authors: Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Chinese Medicine
Subjects:
CNS side effects
Curcumin
Formalin test
Piperine
Synergistic interaction
Tail-flick test
Online Access:https://doi.org/10.1186/s13020-022-00660-1

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