Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation
Improving outcomes in very small children is a major goal of pediatric liver transplantation. This report describes our experience of living related liver transplantation in an infant weighing 3.98 kg. The recipient, a 80-day-old male infant with congenital biliary atresia, was treated with living d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2010-05-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/314195 |
| _version_ | 1818410390854303744 |
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| author | Chunbao Guo Mingman Zhang |
| author_facet | Chunbao Guo Mingman Zhang |
| author_sort | Chunbao Guo |
| collection | DOAJ |
| description | Improving outcomes in very small children is a major goal of pediatric liver transplantation. This report describes our experience of living related liver transplantation in an infant weighing 3.98 kg. The recipient, a 80-day-old male infant with congenital biliary atresia, was treated with living donor liver transplantation and then followed up for 6 months. The left lateral segment (segment II, III) with reduced size from the donor, his 26-year-old mother, was used as the graft. The graft weighed 200 g. The graft weight to recipient body weight ratio was 5.025%. The donor regained her liver function within 3 days and was discharged on day 8. The patient showed good results. Liver function returned to normal 9 days after the operation with bilirubin level almost decreased to normal. Cyclosporin, mycophenolate mofetil and prednisone were used for postoperative immunosuppression. No bleeding, thrombosis, infection or bile leakage occurred. The patient had slight fever because of a little collection in the abdomen and recovered after paracentesis and drainage. He was discharged on day 16. The donor and recipient are in satisfactory condition at present. Improvement of technique in hepatic surgery, microsurgical technique in vascular surgery and postoperative intensive care are the keys to ensure the success of the procedure. |
| first_indexed | 2024-12-14T10:14:46Z |
| format | Article |
| id | doaj.art-b58218f0ea6a46f0a2ae968018b76d16 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-14T10:14:46Z |
| publishDate | 2010-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-b58218f0ea6a46f0a2ae968018b76d162022-12-21T23:06:54ZengKarger PublishersCase Reports in Gastroenterology1662-06312010-05-014215816710.1159/000314195314195Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver TransplantationChunbao GuoMingman ZhangImproving outcomes in very small children is a major goal of pediatric liver transplantation. This report describes our experience of living related liver transplantation in an infant weighing 3.98 kg. The recipient, a 80-day-old male infant with congenital biliary atresia, was treated with living donor liver transplantation and then followed up for 6 months. The left lateral segment (segment II, III) with reduced size from the donor, his 26-year-old mother, was used as the graft. The graft weighed 200 g. The graft weight to recipient body weight ratio was 5.025%. The donor regained her liver function within 3 days and was discharged on day 8. The patient showed good results. Liver function returned to normal 9 days after the operation with bilirubin level almost decreased to normal. Cyclosporin, mycophenolate mofetil and prednisone were used for postoperative immunosuppression. No bleeding, thrombosis, infection or bile leakage occurred. The patient had slight fever because of a little collection in the abdomen and recovered after paracentesis and drainage. He was discharged on day 16. The donor and recipient are in satisfactory condition at present. Improvement of technique in hepatic surgery, microsurgical technique in vascular surgery and postoperative intensive care are the keys to ensure the success of the procedure.http://www.karger.com/Article/FullText/314195InfantBiliary atresiaLiving donorLiver transplantation |
| spellingShingle | Chunbao Guo Mingman Zhang Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation Case Reports in Gastroenterology Infant Biliary atresia Living donor Liver transplantation |
| title | Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation |
| title_full | Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation |
| title_fullStr | Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation |
| title_full_unstemmed | Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation |
| title_short | Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation |
| title_sort | successful treatment of biliary atresia in very small infants through living related liver transplantation |
| topic | Infant Biliary atresia Living donor Liver transplantation |
| url | http://www.karger.com/Article/FullText/314195 |
| work_keys_str_mv | AT chunbaoguo successfultreatmentofbiliaryatresiainverysmallinfantsthroughlivingrelatedlivertransplantation AT mingmanzhang successfultreatmentofbiliaryatresiainverysmallinfantsthroughlivingrelatedlivertransplantation |