HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil
Abstract Background The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil. Aim To estimate the frequency of HLA-B27 in the Brazilian general populatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Advances in Rheumatology |
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| Online Access: | https://doi.org/10.1186/s42358-023-00302-6 |
| _version_ | 1797840810725605376 |
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| author | Gustavo Gomes Resende Carla Gonçalves Schahin Saad Danielli Cristina Muniz de Oliveira Julio Silvio de Sousa Bueno Filho Percival Degrava Sampaio-Barros Marcelo de Medeiros Pinheiro |
| author_facet | Gustavo Gomes Resende Carla Gonçalves Schahin Saad Danielli Cristina Muniz de Oliveira Julio Silvio de Sousa Bueno Filho Percival Degrava Sampaio-Barros Marcelo de Medeiros Pinheiro |
| author_sort | Gustavo Gomes Resende |
| collection | DOAJ |
| description | Abstract Background The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil. Aim To estimate the frequency of HLA-B27 in the Brazilian general population using a large national registry database. Methods This is a cross-sectional ecological study using the Brazilian Registry of Volunteer Bone Marrow Donors (REDOME) database on HLA-B27 allelic frequency and proportion of positives of healthy donors (18–60 years old). Data were analyzed according to sex, age, race (by self-reported skin color recommended by the Brazilian Institute of Geography and Statistics - IBGE), and geographic region of residence. Results From 1994 to 2022, a total of 5,389,143 healthy bone marrow donors were included. The overall positivity for HLA-B27 was 4.35% (CI 95% 4.32–4.37%), regardless of sex and age (57.2% were women, mean age was 41.7yo). However, there was a difference between races: 4.85% in Whites; 2.92% in Blacks; 3.76% in Pardos (Browns i.e. mixed races); 3.95% in Amarelos (Yellows i.e. Asian Brazilians); and 3.18% in Indigenous. There was also a difference regarding geographic region of residence (North: 3.62%; Northeast: 3.63%; Southeast: 4.29%; Midwest: 4.5% and 5.25% in South). The homozygosity rate for the HLA-B27 was 1.32% of all the positives and only 0.06% in the general population. Conclusions Our findings provide the first Brazilian national prevalence for HLA-B27 in 4.35%. There is a gradient gene positivity from North to South, suggesting that the genetic background related to the miscegenation due to colonization, slavery, and some later waves of immigration together with internal migratory flows, could explain our findings. |
| first_indexed | 2024-04-09T16:20:45Z |
| format | Article |
| id | doaj.art-b58445fb165d4ba88b839dc19767e4e1 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-04-09T16:20:45Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-b58445fb165d4ba88b839dc19767e4e12023-04-23T11:32:04ZengBMCAdvances in Rheumatology2523-31062023-04-016311710.1186/s42358-023-00302-6HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in BrazilGustavo Gomes Resende0Carla Gonçalves Schahin Saad1Danielli Cristina Muniz de Oliveira2Julio Silvio de Sousa Bueno Filho3Percival Degrava Sampaio-Barros4Marcelo de Medeiros Pinheiro5Hospital das Clínicas - Universidade Federal de Minas Gerais (HC-UFMG)Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP)Registro Brasileiro de Doadores Voluntários de Medula Óssea (REDOME), Instituto Nacional de Câncer (INCA)Departamento de Estatística, Universidade Federal de Lavras (UFLA)Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP) Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP)Abstract Background The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil. Aim To estimate the frequency of HLA-B27 in the Brazilian general population using a large national registry database. Methods This is a cross-sectional ecological study using the Brazilian Registry of Volunteer Bone Marrow Donors (REDOME) database on HLA-B27 allelic frequency and proportion of positives of healthy donors (18–60 years old). Data were analyzed according to sex, age, race (by self-reported skin color recommended by the Brazilian Institute of Geography and Statistics - IBGE), and geographic region of residence. Results From 1994 to 2022, a total of 5,389,143 healthy bone marrow donors were included. The overall positivity for HLA-B27 was 4.35% (CI 95% 4.32–4.37%), regardless of sex and age (57.2% were women, mean age was 41.7yo). However, there was a difference between races: 4.85% in Whites; 2.92% in Blacks; 3.76% in Pardos (Browns i.e. mixed races); 3.95% in Amarelos (Yellows i.e. Asian Brazilians); and 3.18% in Indigenous. There was also a difference regarding geographic region of residence (North: 3.62%; Northeast: 3.63%; Southeast: 4.29%; Midwest: 4.5% and 5.25% in South). The homozygosity rate for the HLA-B27 was 1.32% of all the positives and only 0.06% in the general population. Conclusions Our findings provide the first Brazilian national prevalence for HLA-B27 in 4.35%. There is a gradient gene positivity from North to South, suggesting that the genetic background related to the miscegenation due to colonization, slavery, and some later waves of immigration together with internal migratory flows, could explain our findings.https://doi.org/10.1186/s42358-023-00302-6HLA-B27BrazilAnkylosing spondylitisBone-marrow donorsEpidemiology |
| spellingShingle | Gustavo Gomes Resende Carla Gonçalves Schahin Saad Danielli Cristina Muniz de Oliveira Julio Silvio de Sousa Bueno Filho Percival Degrava Sampaio-Barros Marcelo de Medeiros Pinheiro HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil Advances in Rheumatology HLA-B27 Brazil Ankylosing spondylitis Bone-marrow donors Epidemiology |
| title | HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil |
| title_full | HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil |
| title_fullStr | HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil |
| title_full_unstemmed | HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil |
| title_short | HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil |
| title_sort | hla b27 positivity in a large miscegenated population of 5 389 143 healthy blood marrow donors in brazil |
| topic | HLA-B27 Brazil Ankylosing spondylitis Bone-marrow donors Epidemiology |
| url | https://doi.org/10.1186/s42358-023-00302-6 |
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