Threading the Pieces Together: Integrative Perspective on SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged the research community globally to innovate, interact, and integrate findings across hierarchies. Research on SARS-CoV-2 has produced an abundance of data spanning multiple parallels, including clinical data, SA...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/11/912 |
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| author | Akshay Kanakan Neha Mishra Janani Srinivasa Vasudevan Shweta Sahni Azka Khan Sachin Sharma Rajesh Pandey |
| author_facet | Akshay Kanakan Neha Mishra Janani Srinivasa Vasudevan Shweta Sahni Azka Khan Sachin Sharma Rajesh Pandey |
| author_sort | Akshay Kanakan |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged the research community globally to innovate, interact, and integrate findings across hierarchies. Research on SARS-CoV-2 has produced an abundance of data spanning multiple parallels, including clinical data, SARS-CoV-2 genome architecture, host response captured through transcriptome and genetic variants, microbial co-infections (metagenome), and comorbidities. Disease phenotypes in the case of COVID-19 present an intriguing complexity that includes a broad range of symptomatic to asymptomatic individuals, further compounded by a vast heterogeneity within the spectrum of clinical symptoms displayed by the symptomatic individuals. The clinical outcome is further modulated by the presence of comorbid conditions at the point of infection. The COVID-19 pandemic has produced an expansive wealth of literature touching many aspects of SARS-CoV-2 ranging from causal to outcome, predisposition to protective (possible), co-infection to comorbidity, and differential mortality globally. As challenges provide opportunities, the current pandemic’s challenge has underscored the need and opportunity to work for an integrative approach that may be able to thread together the multiple variables. Through this review, we have made an effort towards bringing together information spanning across different domains to facilitate researchers globally in pursuit of their response to SARS-CoV-2. |
| first_indexed | 2024-03-10T15:06:24Z |
| format | Article |
| id | doaj.art-b5849226743847cb9274df1e8f1f1b39 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T15:06:24Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-b5849226743847cb9274df1e8f1f1b392023-11-20T19:43:22ZengMDPI AGPathogens2076-08172020-11-0191191210.3390/pathogens9110912Threading the Pieces Together: Integrative Perspective on SARS-CoV-2Akshay Kanakan0Neha Mishra1Janani Srinivasa Vasudevan2Shweta Sahni3Azka Khan4Sachin Sharma5Rajesh Pandey6INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaINtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi 110007, IndiaThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged the research community globally to innovate, interact, and integrate findings across hierarchies. Research on SARS-CoV-2 has produced an abundance of data spanning multiple parallels, including clinical data, SARS-CoV-2 genome architecture, host response captured through transcriptome and genetic variants, microbial co-infections (metagenome), and comorbidities. Disease phenotypes in the case of COVID-19 present an intriguing complexity that includes a broad range of symptomatic to asymptomatic individuals, further compounded by a vast heterogeneity within the spectrum of clinical symptoms displayed by the symptomatic individuals. The clinical outcome is further modulated by the presence of comorbid conditions at the point of infection. The COVID-19 pandemic has produced an expansive wealth of literature touching many aspects of SARS-CoV-2 ranging from causal to outcome, predisposition to protective (possible), co-infection to comorbidity, and differential mortality globally. As challenges provide opportunities, the current pandemic’s challenge has underscored the need and opportunity to work for an integrative approach that may be able to thread together the multiple variables. Through this review, we have made an effort towards bringing together information spanning across different domains to facilitate researchers globally in pursuit of their response to SARS-CoV-2.https://www.mdpi.com/2076-0817/9/11/912SARS-CoV-2host responseco-infectioncomorbidityintegrative genomicsdrugs |
| spellingShingle | Akshay Kanakan Neha Mishra Janani Srinivasa Vasudevan Shweta Sahni Azka Khan Sachin Sharma Rajesh Pandey Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 Pathogens SARS-CoV-2 host response co-infection comorbidity integrative genomics drugs |
| title | Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
| title_full | Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
| title_fullStr | Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
| title_full_unstemmed | Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
| title_short | Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
| title_sort | threading the pieces together integrative perspective on sars cov 2 |
| topic | SARS-CoV-2 host response co-infection comorbidity integrative genomics drugs |
| url | https://www.mdpi.com/2076-0817/9/11/912 |
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