Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection
<i>Helicobacter pylori</i> (<i>H. pylori</i>) can be eradicated immediately while conducting an endoscopic examination. The eradication rate of intraluminal therapy for <i>H. pylori</i> infection (ILTHPI) is 53.7% (51/95) via local application of single-dose medic...
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MDPI AG
2022-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/2/415 |
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| author | Cheng-Yu Ho Ting-Wen Liu Yang-Sheng Lin Yen-Po Chen Ming-Jen Chen Horng-Yuan Wang Tai-Cherng Liou |
| author_facet | Cheng-Yu Ho Ting-Wen Liu Yang-Sheng Lin Yen-Po Chen Ming-Jen Chen Horng-Yuan Wang Tai-Cherng Liou |
| author_sort | Cheng-Yu Ho |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> (<i>H. pylori</i>) can be eradicated immediately while conducting an endoscopic examination. The eradication rate of intraluminal therapy for <i>H. pylori</i> infection (ILTHPI) is 53.7% (51/95) via local application of single-dose medicament containing amoxicillin, metronidazole, and clarithromycin. We aimed to evaluate factors affecting ILTHPI and to assess the efficacy among single antibiotics, and compared our results with combined antibiotics. We enrolled <i>H. pylori</i>-infected treatment-naïve symptomatic patients; 95 completed triple-antibiotic ILTHPI were evaluated for risk factors, along with 60 completed mono-antibiotic ILTHPI containing amoxicillin, clarithromycin, or metronidazole in each of the 20 patients. Univariate analysis revealed the significant influence of BMI (OR: 1.15; 95% CI: 1.03–1.27, <i>p</i> = 0.011) and gastric juice pH (OR: 1.35; 95% CI: 1.16–1.58, <i>p</i> = 0.0001). Logistic regression analysis also showed significant influence of gastric juice pH (OR: 1.30; 95% CI: 1.10–1.54, <i>p</i> = 0.002). The eradication rate of mono-antibiotic ILTHPI is significantly lower than triple-antibiotic ILTHPI (11.7% vs. 53.7%; <i>p</i> < 0.0001; α = 0.05, power = 1.0). The efficacy was 20% (4/20) for metronidazole, 10% (2/20) for amoxicillin, and 5% (1/20) for clarithromycin. In conclusion, the level of gastric juice pH is a crucial factor affecting the ILTHPI. The detection of gastric juice pH and selection of optimal intraluminal medicaments are important. Further studies with combined antibiotics for ILTHPI, perhaps metronidazole-containing medicaments, are recommended. |
| first_indexed | 2024-03-09T21:23:02Z |
| format | Article |
| id | doaj.art-b584a75271ea402295470255b575b58c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T21:23:02Z |
| publishDate | 2022-02-01 |
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| series | Microorganisms |
| spelling | doaj.art-b584a75271ea402295470255b575b58c2023-11-23T21:15:51ZengMDPI AGMicroorganisms2076-26072022-02-0110241510.3390/microorganisms10020415Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> InfectionCheng-Yu Ho0Ting-Wen Liu1Yang-Sheng Lin2Yen-Po Chen3Ming-Jen Chen4Horng-Yuan Wang5Tai-Cherng Liou6Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Tamsui, New Taipei City 25173, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 25245, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 25245, TaiwanDivision of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Tamsui, New Taipei City 25173, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 25245, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 25245, TaiwanDivision of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Tamsui, New Taipei City 25173, Taiwan<i>Helicobacter pylori</i> (<i>H. pylori</i>) can be eradicated immediately while conducting an endoscopic examination. The eradication rate of intraluminal therapy for <i>H. pylori</i> infection (ILTHPI) is 53.7% (51/95) via local application of single-dose medicament containing amoxicillin, metronidazole, and clarithromycin. We aimed to evaluate factors affecting ILTHPI and to assess the efficacy among single antibiotics, and compared our results with combined antibiotics. We enrolled <i>H. pylori</i>-infected treatment-naïve symptomatic patients; 95 completed triple-antibiotic ILTHPI were evaluated for risk factors, along with 60 completed mono-antibiotic ILTHPI containing amoxicillin, clarithromycin, or metronidazole in each of the 20 patients. Univariate analysis revealed the significant influence of BMI (OR: 1.15; 95% CI: 1.03–1.27, <i>p</i> = 0.011) and gastric juice pH (OR: 1.35; 95% CI: 1.16–1.58, <i>p</i> = 0.0001). Logistic regression analysis also showed significant influence of gastric juice pH (OR: 1.30; 95% CI: 1.10–1.54, <i>p</i> = 0.002). The eradication rate of mono-antibiotic ILTHPI is significantly lower than triple-antibiotic ILTHPI (11.7% vs. 53.7%; <i>p</i> < 0.0001; α = 0.05, power = 1.0). The efficacy was 20% (4/20) for metronidazole, 10% (2/20) for amoxicillin, and 5% (1/20) for clarithromycin. In conclusion, the level of gastric juice pH is a crucial factor affecting the ILTHPI. The detection of gastric juice pH and selection of optimal intraluminal medicaments are important. Further studies with combined antibiotics for ILTHPI, perhaps metronidazole-containing medicaments, are recommended.https://www.mdpi.com/2076-2607/10/2/415<i>Helicobacter pylori</i>gastric juiceacidityendoscopytherapyrisk factors |
| spellingShingle | Cheng-Yu Ho Ting-Wen Liu Yang-Sheng Lin Yen-Po Chen Ming-Jen Chen Horng-Yuan Wang Tai-Cherng Liou Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection Microorganisms <i>Helicobacter pylori</i> gastric juice acidity endoscopy therapy risk factors |
| title | Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection |
| title_full | Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection |
| title_fullStr | Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection |
| title_full_unstemmed | Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection |
| title_short | Factors Affecting the Intraluminal Therapy for <i>Helicobacter pylori</i> Infection |
| title_sort | factors affecting the intraluminal therapy for i helicobacter pylori i infection |
| topic | <i>Helicobacter pylori</i> gastric juice acidity endoscopy therapy risk factors |
| url | https://www.mdpi.com/2076-2607/10/2/415 |
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