Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes
Abstract Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence su...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202300325 |
| _version_ | 1797736293978865664 |
|---|---|
| author | Yumin Wang Shuang Wu Qiang Li Huiyan Sun Hongquan Wang |
| author_facet | Yumin Wang Shuang Wu Qiang Li Huiyan Sun Hongquan Wang |
| author_sort | Yumin Wang |
| collection | DOAJ |
| description | Abstract Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence supports ferroptosis as a critical factor of neurodegenerative diseases and strokes, and pharmacological inhibition of ferroptosis as a therapeutic target for these diseases. In this review article, the core mechanisms of ferroptosis are overviewed and the roles of ferroptosis in neurodegenerative diseases and strokes are described. Finally, the emerging findings in treating neurodegenerative diseases and strokes through pharmacological inhibition of ferroptosis are described. This review demonstrates that pharmacological inhibition of ferroptosis by bioactive small‐molecule compounds (ferroptosis inhibitors) could be effective for treatments of these diseases, and highlights a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes. This review article will shed light on developing novel therapeutic regimens by pharmacological inhibition of ferroptosis to slow down the progression of these diseases in the future. |
| first_indexed | 2024-03-12T13:10:32Z |
| format | Article |
| id | doaj.art-b5868c408c0d4a178632bf0b7c6fc074 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T13:10:32Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b5868c408c0d4a178632bf0b7c6fc0742023-08-28T03:36:35ZengWileyAdvanced Science2198-38442023-08-011024n/an/a10.1002/advs.202300325Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and StrokesYumin Wang0Shuang Wu1Qiang Li2Huiyan Sun3Hongquan Wang4Department of Respiratory and Critical Care Medicine Aerospace Center Hospital Peking University Aerospace School of Clinical Medicine Beijing 100049 P. R. ChinaDepartment of Neurology Zhongnan Hospital of Wuhan University Wuhan 430000 P. R. ChinaDepartment of Neurology The Affiliated Hospital of Chifeng University Chifeng 024005 P. R. ChinaChifeng University Health Science Center Chifeng 024000 P. R. ChinaTianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 P. R. ChinaAbstract Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence supports ferroptosis as a critical factor of neurodegenerative diseases and strokes, and pharmacological inhibition of ferroptosis as a therapeutic target for these diseases. In this review article, the core mechanisms of ferroptosis are overviewed and the roles of ferroptosis in neurodegenerative diseases and strokes are described. Finally, the emerging findings in treating neurodegenerative diseases and strokes through pharmacological inhibition of ferroptosis are described. This review demonstrates that pharmacological inhibition of ferroptosis by bioactive small‐molecule compounds (ferroptosis inhibitors) could be effective for treatments of these diseases, and highlights a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes. This review article will shed light on developing novel therapeutic regimens by pharmacological inhibition of ferroptosis to slow down the progression of these diseases in the future.https://doi.org/10.1002/advs.202300325Alzheimer's diseaseamyotrophic lateral sclerosisferroptosisintracerebral hemorrhageischemic strokeParkinson's disease |
| spellingShingle | Yumin Wang Shuang Wu Qiang Li Huiyan Sun Hongquan Wang Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes Advanced Science Alzheimer's disease amyotrophic lateral sclerosis ferroptosis intracerebral hemorrhage ischemic stroke Parkinson's disease |
| title | Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes |
| title_full | Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes |
| title_fullStr | Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes |
| title_full_unstemmed | Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes |
| title_short | Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes |
| title_sort | pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes |
| topic | Alzheimer's disease amyotrophic lateral sclerosis ferroptosis intracerebral hemorrhage ischemic stroke Parkinson's disease |
| url | https://doi.org/10.1002/advs.202300325 |
| work_keys_str_mv | AT yuminwang pharmacologicalinhibitionofferroptosisasatherapeutictargetforneurodegenerativediseasesandstrokes AT shuangwu pharmacologicalinhibitionofferroptosisasatherapeutictargetforneurodegenerativediseasesandstrokes AT qiangli pharmacologicalinhibitionofferroptosisasatherapeutictargetforneurodegenerativediseasesandstrokes AT huiyansun pharmacologicalinhibitionofferroptosisasatherapeutictargetforneurodegenerativediseasesandstrokes AT hongquanwang pharmacologicalinhibitionofferroptosisasatherapeutictargetforneurodegenerativediseasesandstrokes |