Biochemical and genetic studies define the functions of methylthiotransferases in methanogenic and methanotrophic archaea

Biochemical and genetic studies define the functions of methylthiotransferases in methanogenic and methanotrophic archaea

Methylthiotransferases (MTTases) are radical S-adenosylmethionine (SAM) enzymes that catalyze the addition of a methylthio (-SCH3) group to an unreactive carbon center. These enzymes are responsible for the production of 2-methylthioadenosine (ms2A) derivatives found at position A37 of select tRNAs...

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Bibliographic Details
Main Authors: Kaleb Boswinkle, Thuc-Anh Dinh, Kylie D. Allen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Microbiology
Subjects:
methanogens
ANME archaea
methylthiotransferases
radical SAM enzymes
tRNA modifications
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1304671/full

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