Alkaloids from Hippeastrum papilio
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for gala...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/8/7097/ |
| _version_ | 1818153691863056384 |
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| author | Jaume Bastida Jean Paulo de Andrade José Angelo S. Zuanazzi Carles Codina Francesc Viladomat Strahil Berkov |
| author_facet | Jaume Bastida Jean Paulo de Andrade José Angelo S. Zuanazzi Carles Codina Francesc Viladomat Strahil Berkov |
| author_sort | Jaume Bastida |
| collection | DOAJ |
| description | Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine. |
| first_indexed | 2024-12-11T14:14:39Z |
| format | Article |
| id | doaj.art-b586f1f083a14bba8ed575cbb0e63264 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T14:14:39Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b586f1f083a14bba8ed575cbb0e632642022-12-22T01:03:14ZengMDPI AGMolecules1420-30492011-08-011687097710410.3390/molecules16087097Alkaloids from Hippeastrum papilioJaume BastidaJean Paulo de AndradeJosé Angelo S. ZuanazziCarles CodinaFrancesc ViladomatStrahil BerkovGalanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.http://www.mdpi.com/1420-3049/16/8/7097/11β-hydroxygalanthamineHippeastrum papilio2D NMR |
| spellingShingle | Jaume Bastida Jean Paulo de Andrade José Angelo S. Zuanazzi Carles Codina Francesc Viladomat Strahil Berkov Alkaloids from Hippeastrum papilio Molecules 11β-hydroxygalanthamine Hippeastrum papilio 2D NMR |
| title | Alkaloids from Hippeastrum papilio |
| title_full | Alkaloids from Hippeastrum papilio |
| title_fullStr | Alkaloids from Hippeastrum papilio |
| title_full_unstemmed | Alkaloids from Hippeastrum papilio |
| title_short | Alkaloids from Hippeastrum papilio |
| title_sort | alkaloids from hippeastrum papilio |
| topic | 11β-hydroxygalanthamine Hippeastrum papilio 2D NMR |
| url | http://www.mdpi.com/1420-3049/16/8/7097/ |
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