Drug-Induced Anaphylaxis in Children
Drug-induced anaphylaxis in children is less common than in adults and primarily involves beta-lactams and nonsteroidal anti-inflammatory drugs. Epidemiological studies show variable prevalence, influenced by age, gender, and atopic diseases. The pathophysiology includes IgE-mediated reactions and n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/527 |
| _version_ | 1827306977331511296 |
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| author | Annamaria Bianchi Rocco Valluzzi Giuseppe Crisafulli Paolo Bottau Silvia Caimmi Fabrizio Franceschini Lucia Liotti Francesca Mori Sara Riscassi Francesca Saretta Sara Scavone Carlo Caffarelli |
| author_facet | Annamaria Bianchi Rocco Valluzzi Giuseppe Crisafulli Paolo Bottau Silvia Caimmi Fabrizio Franceschini Lucia Liotti Francesca Mori Sara Riscassi Francesca Saretta Sara Scavone Carlo Caffarelli |
| author_sort | Annamaria Bianchi |
| collection | DOAJ |
| description | Drug-induced anaphylaxis in children is less common than in adults and primarily involves beta-lactams and nonsteroidal anti-inflammatory drugs. Epidemiological studies show variable prevalence, influenced by age, gender, and atopic diseases. The pathophysiology includes IgE-mediated reactions and non-IgE mechanisms, like cytokine release reactions. We address drug-induced anaphylaxis in children, focusing on antibiotics, nonsteroidal anti-inflammatory drugs, neuromuscular blocking agents, and monoclonal antibodies. Diagnosis combines clinical criteria with in vitro, in vivo, and drug provocation tests. The immediate management of acute anaphylaxis primarily involves the use of adrenaline, coupled with long-term strategies, such as allergen avoidance and patient education. Desensitization protocols are crucial for children allergic to essential medications, particularly antibiotics and chemotherapy agents. |
| first_indexed | 2024-04-24T18:32:37Z |
| format | Article |
| id | doaj.art-b5870b5b5efa4422af1cc42b47c39f4c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:32:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b5870b5b5efa4422af1cc42b47c39f4c2024-03-27T13:22:41ZengMDPI AGBiomedicines2227-90592024-02-0112352710.3390/biomedicines12030527Drug-Induced Anaphylaxis in ChildrenAnnamaria Bianchi0Rocco Valluzzi1Giuseppe Crisafulli2Paolo Bottau3Silvia Caimmi4Fabrizio Franceschini5Lucia Liotti6Francesca Mori7Sara Riscassi8Francesca Saretta9Sara Scavone10Carlo Caffarelli11UOC Pediatria, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, ItalyTranslational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, 00152 Roma, ItalyUOC di Pediatria, Dipartimento Materno-Infantile, Università di Messina, 98100 Messina, ItalyUOC di Pediatria e Neonatologia, Ospedale di Imola (BO), 40026 Imola, ItalySC di Pediatria Fondazione IRCSS Policlinico San Matteo, 27100 Pavia, ItalyUOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60123 Ancona, ItalyUOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60123 Ancona, ItalyAllergy Unit, Meyer Children’s Hospital IRCCS, 50132 Florence, ItalyUOC di Pediatria Ospedale di Bolzano, Azienda Sanitaria dell’Alto Adige, 39100 Bolzano, ItalySC Pediatria, Ospedale Latisana-Palmanova, Dipartimento Materno-Infantile Azienda Sanitaria, Universitaria Friuli Centrale, 33100 Udine, ItalyClinica Pediatrica, Dipartimento Medicina e Chirurgia, University of Parma, 43126 Parma, ItalyClinica Pediatrica, Dipartimento Medicina e Chirurgia, University of Parma, 43126 Parma, ItalyDrug-induced anaphylaxis in children is less common than in adults and primarily involves beta-lactams and nonsteroidal anti-inflammatory drugs. Epidemiological studies show variable prevalence, influenced by age, gender, and atopic diseases. The pathophysiology includes IgE-mediated reactions and non-IgE mechanisms, like cytokine release reactions. We address drug-induced anaphylaxis in children, focusing on antibiotics, nonsteroidal anti-inflammatory drugs, neuromuscular blocking agents, and monoclonal antibodies. Diagnosis combines clinical criteria with in vitro, in vivo, and drug provocation tests. The immediate management of acute anaphylaxis primarily involves the use of adrenaline, coupled with long-term strategies, such as allergen avoidance and patient education. Desensitization protocols are crucial for children allergic to essential medications, particularly antibiotics and chemotherapy agents.https://www.mdpi.com/2227-9059/12/3/527anaphylaxisdrugchildrenhypersensitivity reactiondrug-induced anaphylaxis |
| spellingShingle | Annamaria Bianchi Rocco Valluzzi Giuseppe Crisafulli Paolo Bottau Silvia Caimmi Fabrizio Franceschini Lucia Liotti Francesca Mori Sara Riscassi Francesca Saretta Sara Scavone Carlo Caffarelli Drug-Induced Anaphylaxis in Children Biomedicines anaphylaxis drug children hypersensitivity reaction drug-induced anaphylaxis |
| title | Drug-Induced Anaphylaxis in Children |
| title_full | Drug-Induced Anaphylaxis in Children |
| title_fullStr | Drug-Induced Anaphylaxis in Children |
| title_full_unstemmed | Drug-Induced Anaphylaxis in Children |
| title_short | Drug-Induced Anaphylaxis in Children |
| title_sort | drug induced anaphylaxis in children |
| topic | anaphylaxis drug children hypersensitivity reaction drug-induced anaphylaxis |
| url | https://www.mdpi.com/2227-9059/12/3/527 |
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