Combined Cell Therapy in the Treatment of Neurological Disorders
Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/12/613 |
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| author | Daria D. Namestnikova Elvira A. Cherkashova Kirill K. Sukhinich Ilya L. Gubskiy Georgy E. Leonov Leonid V. Gubsky Alexander G. Majouga Konstantin N. Yarygin |
| author_facet | Daria D. Namestnikova Elvira A. Cherkashova Kirill K. Sukhinich Ilya L. Gubskiy Georgy E. Leonov Leonid V. Gubsky Alexander G. Majouga Konstantin N. Yarygin |
| author_sort | Daria D. Namestnikova |
| collection | DOAJ |
| description | Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. The advantages of combined cell therapy can be realized by simple summation of beneficial effects of different cells. Alternatively, one kind of cells can support the survival and functioning of the other by enhancing the formation of optimum environment or immunomodulation. No significant adverse events were reported. Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted. |
| first_indexed | 2024-03-10T14:04:13Z |
| format | Article |
| id | doaj.art-b58937b7cf724ff2a496278d2e5f4765 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:04:13Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b58937b7cf724ff2a496278d2e5f47652023-11-21T00:51:12ZengMDPI AGBiomedicines2227-90592020-12-0181261310.3390/biomedicines8120613Combined Cell Therapy in the Treatment of Neurological DisordersDaria D. Namestnikova0Elvira A. Cherkashova1Kirill K. Sukhinich2Ilya L. Gubskiy3Georgy E. Leonov4Leonid V. Gubsky5Alexander G. Majouga6Konstantin N. Yarygin7Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaRadiology and Clinical Physiology Scientific Research Center, Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russian Federation, 117997 Moscow, RussiaLaboratory of Problems of Regeneration, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 119334 Moscow, RussiaRadiology and Clinical Physiology Scientific Research Center, Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russian Federation, 117997 Moscow, RussiaDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaD. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, RussiaLaboratory of Cell Biology, Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Sciences, 119435 Moscow, RussiaCell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. The advantages of combined cell therapy can be realized by simple summation of beneficial effects of different cells. Alternatively, one kind of cells can support the survival and functioning of the other by enhancing the formation of optimum environment or immunomodulation. No significant adverse events were reported. Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted.https://www.mdpi.com/2227-9059/8/12/613neurological diseasescell therapycombined therapybinary therapytransplantation |
| spellingShingle | Daria D. Namestnikova Elvira A. Cherkashova Kirill K. Sukhinich Ilya L. Gubskiy Georgy E. Leonov Leonid V. Gubsky Alexander G. Majouga Konstantin N. Yarygin Combined Cell Therapy in the Treatment of Neurological Disorders Biomedicines neurological diseases cell therapy combined therapy binary therapy transplantation |
| title | Combined Cell Therapy in the Treatment of Neurological Disorders |
| title_full | Combined Cell Therapy in the Treatment of Neurological Disorders |
| title_fullStr | Combined Cell Therapy in the Treatment of Neurological Disorders |
| title_full_unstemmed | Combined Cell Therapy in the Treatment of Neurological Disorders |
| title_short | Combined Cell Therapy in the Treatment of Neurological Disorders |
| title_sort | combined cell therapy in the treatment of neurological disorders |
| topic | neurological diseases cell therapy combined therapy binary therapy transplantation |
| url | https://www.mdpi.com/2227-9059/8/12/613 |
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