Bioactivities of extracts from the marine sponge Halichondria panicea
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was de...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SciELO
2009-01-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300007 |
| _version_ | 1819172011167973376 |
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| author | GB Purushottama K Venkateshvaran K Pani Prasad P Nalini |
| author_facet | GB Purushottama K Venkateshvaran K Pani Prasad P Nalini |
| author_sort | GB Purushottama |
| collection | DOAJ |
| description | In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel. |
| first_indexed | 2024-12-22T20:00:24Z |
| format | Article |
| id | doaj.art-b5899e35bf3d4c9d93cdd9ea86495446 |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-12-22T20:00:24Z |
| publishDate | 2009-01-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-b5899e35bf3d4c9d93cdd9ea864954462022-12-21T18:14:17ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992009-01-0115344445910.1590/S1678-91992009000300007Bioactivities of extracts from the marine sponge Halichondria paniceaGB PurushottamaK VenkateshvaranK Pani PrasadP NaliniIn the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300007Halichondria paniceaphagocytosisneuromodulationhemolysisangiogenesis |
| spellingShingle | GB Purushottama K Venkateshvaran K Pani Prasad P Nalini Bioactivities of extracts from the marine sponge Halichondria panicea Journal of Venomous Animals and Toxins including Tropical Diseases Halichondria panicea phagocytosis neuromodulation hemolysis angiogenesis |
| title | Bioactivities of extracts from the marine sponge Halichondria panicea |
| title_full | Bioactivities of extracts from the marine sponge Halichondria panicea |
| title_fullStr | Bioactivities of extracts from the marine sponge Halichondria panicea |
| title_full_unstemmed | Bioactivities of extracts from the marine sponge Halichondria panicea |
| title_short | Bioactivities of extracts from the marine sponge Halichondria panicea |
| title_sort | bioactivities of extracts from the marine sponge halichondria panicea |
| topic | Halichondria panicea phagocytosis neuromodulation hemolysis angiogenesis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300007 |
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