Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation

Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation

Background: Antibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear. Method: We analyzed post-transplant sequencing and clinical data from GEO and ArrayExpress. Using dimensionality reduction...

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Bibliographic Details
Main Authors: Qidan Pang, Liang Chen, Changyong An, Juan Zhou, Hanyu Xiao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Macrophage
Antibody-mediated rejection
Single-cell
Kidney transplantation
Graft loss
Biopsies for cause
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024038969

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http://www.sciencedirect.com/science/article/pii/S2405844024038969

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