A peculiar case of psychosis: anti-NMDAr encephalitis
Abstract Background Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
|
| Series: | International Journal of Emergency Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12245-021-00389-y |
| _version_ | 1818833590142631936 |
|---|---|
| author | Lamia Kouba Dalia Alhosain |
| author_facet | Lamia Kouba Dalia Alhosain |
| author_sort | Lamia Kouba |
| collection | DOAJ |
| description | Abstract Background Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy. Case presentation A 20-year-old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis 6 weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high-dose corticosteroids and plasmapheresis, and she was discharged 2 weeks later fully recovered. Conclusions Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial. |
| first_indexed | 2024-12-19T02:21:20Z |
| format | Article |
| id | doaj.art-b58aadeee27648afab1f87fe93592249 |
| institution | Directory Open Access Journal |
| issn | 1865-1372 1865-1380 |
| language | English |
| last_indexed | 2024-12-19T02:21:20Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Emergency Medicine |
| spelling | doaj.art-b58aadeee27648afab1f87fe935922492022-12-21T20:40:11ZengBMCInternational Journal of Emergency Medicine1865-13721865-13802021-11-011411310.1186/s12245-021-00389-yA peculiar case of psychosis: anti-NMDAr encephalitisLamia Kouba0Dalia Alhosain1Department of Dermatology, Damascus University HospitalsDepartment of Internal Medicine, Damascus University HospitalsAbstract Background Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy. Case presentation A 20-year-old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis 6 weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high-dose corticosteroids and plasmapheresis, and she was discharged 2 weeks later fully recovered. Conclusions Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial.https://doi.org/10.1186/s12245-021-00389-yAnti-NMDA receptor encephalitisHerpes simplex virusPsychosisPregnancyCase report |
| spellingShingle | Lamia Kouba Dalia Alhosain A peculiar case of psychosis: anti-NMDAr encephalitis International Journal of Emergency Medicine Anti-NMDA receptor encephalitis Herpes simplex virus Psychosis Pregnancy Case report |
| title | A peculiar case of psychosis: anti-NMDAr encephalitis |
| title_full | A peculiar case of psychosis: anti-NMDAr encephalitis |
| title_fullStr | A peculiar case of psychosis: anti-NMDAr encephalitis |
| title_full_unstemmed | A peculiar case of psychosis: anti-NMDAr encephalitis |
| title_short | A peculiar case of psychosis: anti-NMDAr encephalitis |
| title_sort | peculiar case of psychosis anti nmdar encephalitis |
| topic | Anti-NMDA receptor encephalitis Herpes simplex virus Psychosis Pregnancy Case report |
| url | https://doi.org/10.1186/s12245-021-00389-y |
| work_keys_str_mv | AT lamiakouba apeculiarcaseofpsychosisantinmdarencephalitis AT daliaalhosain apeculiarcaseofpsychosisantinmdarencephalitis AT lamiakouba peculiarcaseofpsychosisantinmdarencephalitis AT daliaalhosain peculiarcaseofpsychosisantinmdarencephalitis |