Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp.
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of Tocantins State. PCM was prevalent in males and r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/5/502 |
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| author | Alessandra G. Krakhecke-Teixeira Danielle H. Yamauchi Alexsandra Rossi Herdson R. de Sousa Hans G. Garces Joaquim L. Júnior Antônio O. S. Júnior Maria Sueli S. Felipe Eduardo Bagagli Heitor F. de Andrade Marcus de M. Teixeira |
| author_facet | Alessandra G. Krakhecke-Teixeira Danielle H. Yamauchi Alexsandra Rossi Herdson R. de Sousa Hans G. Garces Joaquim L. Júnior Antônio O. S. Júnior Maria Sueli S. Felipe Eduardo Bagagli Heitor F. de Andrade Marcus de M. Teixeira |
| author_sort | Alessandra G. Krakhecke-Teixeira |
| collection | DOAJ |
| description | Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of Tocantins State. PCM was prevalent in males and rural workers over 50 years; the chronic pulmonary form predominated in 67% of cases. The male-to-female ratio was 2.65:1, with more women affected than other endemic regions of Brazil. Urban or indoor activities were reported in women and are ascribed to disease urbanization. qPCR-based assays confirmed the identification of Paracoccidioides DNA in 37 biological specimens. Paracoccidioides sp. DNA was found in 53% of the environmental samples, suggesting autochthonous infections. Therefore, the Tocantins-Araguaia basin must be considered a novel hyperendemic area of PCM in Brazil, reinforcing the importance of including PCM as a notifiable disease, requiring specific diagnosis and health measures. |
| first_indexed | 2024-03-10T03:36:59Z |
| format | Article |
| id | doaj.art-b58b2dc726734d08ade2c4bef71073b7 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:36:59Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b58b2dc726734d08ade2c4bef71073b72023-11-23T11:42:02ZengMDPI AGJournal of Fungi2309-608X2022-05-018550210.3390/jof8050502Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp.Alessandra G. Krakhecke-Teixeira0Danielle H. Yamauchi1Alexsandra Rossi2Herdson R. de Sousa3Hans G. Garces4Joaquim L. Júnior5Antônio O. S. Júnior6Maria Sueli S. Felipe7Eduardo Bagagli8Heitor F. de Andrade9Marcus de M. Teixeira10Tocantins Department of Public Health, Palmas 77015-007, TO, BrazilDepartment of Chemical and Biological Sciences, São Paulo State University “Júlio de Mesquita Filho”, Botucatu 18618-687, SP, BrazilTocantins Department of Public Health, Palmas 77015-007, TO, BrazilNúcleo de Medicina Tropical, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília 70910-900, DF, BrazilDepartment of Chemical and Biological Sciences, São Paulo State University “Júlio de Mesquita Filho”, Botucatu 18618-687, SP, BrazilOswaldo Cruz Foundation (Fiocruz), Brasília 70904-130, DF, BrazilMedical School, Federal University of Tocantins, Araguaína 77402-970, TO, BrazilGraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília 70790-160, DF, BrazilDepartment of Chemical and Biological Sciences, São Paulo State University “Júlio de Mesquita Filho”, Botucatu 18618-687, SP, BrazilInstitute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, SP, BrazilNúcleo de Medicina Tropical, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília 70910-900, DF, BrazilParacoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of Tocantins State. PCM was prevalent in males and rural workers over 50 years; the chronic pulmonary form predominated in 67% of cases. The male-to-female ratio was 2.65:1, with more women affected than other endemic regions of Brazil. Urban or indoor activities were reported in women and are ascribed to disease urbanization. qPCR-based assays confirmed the identification of Paracoccidioides DNA in 37 biological specimens. Paracoccidioides sp. DNA was found in 53% of the environmental samples, suggesting autochthonous infections. Therefore, the Tocantins-Araguaia basin must be considered a novel hyperendemic area of PCM in Brazil, reinforcing the importance of including PCM as a notifiable disease, requiring specific diagnosis and health measures.https://www.mdpi.com/2309-608X/8/5/502Tocantins-Araguaia basin<i>Paracoccidioides brasiliensis</i><i>Paracoccidioides lutzii</i>paracoccidioidomycosisNorthern Brazil |
| spellingShingle | Alessandra G. Krakhecke-Teixeira Danielle H. Yamauchi Alexsandra Rossi Herdson R. de Sousa Hans G. Garces Joaquim L. Júnior Antônio O. S. Júnior Maria Sueli S. Felipe Eduardo Bagagli Heitor F. de Andrade Marcus de M. Teixeira Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. Journal of Fungi Tocantins-Araguaia basin <i>Paracoccidioides brasiliensis</i> <i>Paracoccidioides lutzii</i> paracoccidioidomycosis Northern Brazil |
| title | Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. |
| title_full | Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. |
| title_fullStr | Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. |
| title_full_unstemmed | Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. |
| title_short | Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by <i>Paracoccidioides</i> sp. |
| title_sort | clinical and eco epidemiological aspects of a novel hyperendemic area of paracoccidioidomycosis in the tocantins araguaia basin northern brazil caused by i paracoccidioides i sp |
| topic | Tocantins-Araguaia basin <i>Paracoccidioides brasiliensis</i> <i>Paracoccidioides lutzii</i> paracoccidioidomycosis Northern Brazil |
| url | https://www.mdpi.com/2309-608X/8/5/502 |
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