CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

Abstract Background Skeletal muscle‐secreted myokines widely participate in lipids metabolism through autocrine, paracrine and endocrine actions. The myokines represented by FGF21 and Irisin can promote the browning of adipocytes and serve as promising targets for treating obesity. Although recombin...

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Bibliographic Details
Main Authors: Hongtao Zhu, Dan Liu, Ming Sui, Meiling Zhou, Beibei Wang, Qinqin Qi, Ting Wang, Guo Zhang, Feng Wan, Bin Zhang
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Clinical and Translational Medicine
Subjects:
adipocyte
browning
CRISPRa
myokines
Online Access:https://doi.org/10.1002/ctm2.1326

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