Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women
Background: Serum uric acid (SUA) levels has been considered a possible risk factor for coronary artery disease (CAD) for many years. Since SUA levels are greatly affected by medications, diet, and metabolism, the association between SUA and CAD has been controversial for centuries. While, the state...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-06-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307222 |
| _version_ | 1818476454363529216 |
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| author | Qianyun Guo Yang Liu Xunxun Feng Jiaqi Yang Guangyao Zhai Yujie Zhou |
| author_facet | Qianyun Guo Yang Liu Xunxun Feng Jiaqi Yang Guangyao Zhai Yujie Zhou |
| author_sort | Qianyun Guo |
| collection | DOAJ |
| description | Background: Serum uric acid (SUA) levels has been considered a possible risk factor for coronary artery disease (CAD) for many years. Since SUA levels are greatly affected by medications, diet, and metabolism, the association between SUA and CAD has been controversial for centuries. While, the state of hyperuricemia (HUA) has been proven to have a negative impact on CAD in previous studies, there are still few clinical and epidemiological studies of HUA in CAD. In particular, evidence of this association is limited in postmenopausal women. This study explored the influence of SUA levels and HUA on CAD in this demographic group. Methods: In total, 5435 postmenopausal women were allocated to either a non-CAD group (n = 2021) or a CAD group (n = 3414). Regression analyses, including generalized linear models (GLM), correlation analysis, comparison between stratified groups, and analysis by use of diuretics were carried out on data obtained in this study. Results: SUA and HUA were found to associate significantly with CAD by univariate logistic regression analysis. In addition, GLM showed nonlinear response of CAD probability with increasing level of SUA. In multivariate analysis, we found that SUA and HUA were independently related to CAD. Correlation analysis showed that SUA and HUA both correlated positively with CAD (p < 0.001). By comparing the stratified age groups, we found that the differences among the age groups were significant (p < 0.05). Conclusions: SUA and HUA were shown to be independently associated with CAD among postmenopausal women. |
| first_indexed | 2024-12-10T09:25:56Z |
| format | Article |
| id | doaj.art-b58c61e8e25e457aacd2b3fea6a7eee2 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-12-10T09:25:56Z |
| publishDate | 2022-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-b58c61e8e25e457aacd2b3fea6a7eee22022-12-22T01:54:31ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-06-0123722210.31083/j.rcm2307222S1530-6550(22)00513-0Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal WomenQianyun Guo0Yang Liu1Xunxun Feng2Jiaqi Yang3Guangyao Zhai4Yujie Zhou5Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, 100029 Beijing, ChinaBackground: Serum uric acid (SUA) levels has been considered a possible risk factor for coronary artery disease (CAD) for many years. Since SUA levels are greatly affected by medications, diet, and metabolism, the association between SUA and CAD has been controversial for centuries. While, the state of hyperuricemia (HUA) has been proven to have a negative impact on CAD in previous studies, there are still few clinical and epidemiological studies of HUA in CAD. In particular, evidence of this association is limited in postmenopausal women. This study explored the influence of SUA levels and HUA on CAD in this demographic group. Methods: In total, 5435 postmenopausal women were allocated to either a non-CAD group (n = 2021) or a CAD group (n = 3414). Regression analyses, including generalized linear models (GLM), correlation analysis, comparison between stratified groups, and analysis by use of diuretics were carried out on data obtained in this study. Results: SUA and HUA were found to associate significantly with CAD by univariate logistic regression analysis. In addition, GLM showed nonlinear response of CAD probability with increasing level of SUA. In multivariate analysis, we found that SUA and HUA were independently related to CAD. Correlation analysis showed that SUA and HUA both correlated positively with CAD (p < 0.001). By comparing the stratified age groups, we found that the differences among the age groups were significant (p < 0.05). Conclusions: SUA and HUA were shown to be independently associated with CAD among postmenopausal women.https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307222serum uric acidhyperuricemiapostmenopausal womencoronary artery disease |
| spellingShingle | Qianyun Guo Yang Liu Xunxun Feng Jiaqi Yang Guangyao Zhai Yujie Zhou Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women Reviews in Cardiovascular Medicine serum uric acid hyperuricemia postmenopausal women coronary artery disease |
| title | Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women |
| title_full | Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women |
| title_fullStr | Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women |
| title_full_unstemmed | Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women |
| title_short | Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women |
| title_sort | serum uric acid and hyperuricemia associate with coronary artery disease among postmenopausal women |
| topic | serum uric acid hyperuricemia postmenopausal women coronary artery disease |
| url | https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307222 |
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