Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development
Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell deve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.623280/full |
| _version_ | 1818927258902986752 |
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| author | Huishan Tao Lei Li Nan-Shih Liao Kimberly S. Schluns Shirley Luckhart John W. Sleasman Xiao-Ping Zhong Xiao-Ping Zhong Xiao-Ping Zhong |
| author_facet | Huishan Tao Lei Li Nan-Shih Liao Kimberly S. Schluns Shirley Luckhart John W. Sleasman Xiao-Ping Zhong Xiao-Ping Zhong Xiao-Ping Zhong |
| author_sort | Huishan Tao |
| collection | DOAJ |
| description | Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell development is unclear. Analyses of publicly available databases have revealed expression of transcripts at various levels of many cytokines and cytokine receptors such as IL-15, IL-15Rα, IL-13, and IL-23a in both human and mouse TECs. Ablation of either IL-15 or IL-15Rα in TECs selectively impairs type 1 innate like T cell, such as iNKT1 and γδT1 cell, development in the thymus, indicating that TECs not only serve as an important source of IL-15 but also trans-present IL-15 to ensure type 1 innate like T cell development. Because type 1 innate like T cells are proinflammatory, our data suggest the possibility that TEC may intrinsically control thymic inflammatory innate like T cells to influence thymic environment. |
| first_indexed | 2024-12-20T03:10:10Z |
| format | Article |
| id | doaj.art-b58dce0700ca4db1ad96277b6f4060f6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T03:10:10Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b58dce0700ca4db1ad96277b6f4060f62022-12-21T19:55:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.623280623280Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell DevelopmentHuishan Tao0Lei Li1Nan-Shih Liao2Kimberly S. Schluns3Shirley Luckhart4John W. Sleasman5Xiao-Ping Zhong6Xiao-Ping Zhong7Xiao-Ping Zhong8Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, United StatesDepartment of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, United StatesInstitute of Molecular Biology, Academia Sinica, Taipei, TaiwanDepartment of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Entomology, Plant Pathology and Nematology, Department of Biological Sciences, University of Idaho, Moscow, ID, United StatesDepartment of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, United StatesDepartment of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, United StatesDepartment of Immunology, Duke University Medical Center, Durham, NC, United StatesDuke Cancer Institute, Duke University Medical Center, Durham, NC, United StatesExpression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell development is unclear. Analyses of publicly available databases have revealed expression of transcripts at various levels of many cytokines and cytokine receptors such as IL-15, IL-15Rα, IL-13, and IL-23a in both human and mouse TECs. Ablation of either IL-15 or IL-15Rα in TECs selectively impairs type 1 innate like T cell, such as iNKT1 and γδT1 cell, development in the thymus, indicating that TECs not only serve as an important source of IL-15 but also trans-present IL-15 to ensure type 1 innate like T cell development. Because type 1 innate like T cells are proinflammatory, our data suggest the possibility that TEC may intrinsically control thymic inflammatory innate like T cells to influence thymic environment.https://www.frontiersin.org/articles/10.3389/fimmu.2021.623280/fullIL-15IL-15Rαthymic epithelial cellsiNKT cellsγδT cellstype 1 innate like T cells |
| spellingShingle | Huishan Tao Lei Li Nan-Shih Liao Kimberly S. Schluns Shirley Luckhart John W. Sleasman Xiao-Ping Zhong Xiao-Ping Zhong Xiao-Ping Zhong Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development Frontiers in Immunology IL-15 IL-15Rα thymic epithelial cells iNKT cells γδT cells type 1 innate like T cells |
| title | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development |
| title_full | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development |
| title_fullStr | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development |
| title_full_unstemmed | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development |
| title_short | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development |
| title_sort | thymic epithelial cell derived il 15 and il 15 receptor α chain foster local environment for type 1 innate like t cell development |
| topic | IL-15 IL-15Rα thymic epithelial cells iNKT cells γδT cells type 1 innate like T cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.623280/full |
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