Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development

Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development

Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell deve...

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Bibliographic Details
Main Authors: Huishan Tao, Lei Li, Nan-Shih Liao, Kimberly S. Schluns, Shirley Luckhart, John W. Sleasman, Xiao-Ping Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
IL-15
IL-15Rα
thymic epithelial cells
iNKT cells
γδT cells
type 1 innate like T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.623280/full

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