The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens
Summary: We examine synaptic connectivity and cocaine-evoked plasticity at specific networks within the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny neurons (MSNs) that project to either the ventral pallidum (D1+VP) or the ventral tegmental area (D1+VTA). We show...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-08-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719309787 |
| _version_ | 1819111609739509760 |
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| author | Corey Baimel Laura M. McGarry Adam G. Carter |
| author_facet | Corey Baimel Laura M. McGarry Adam G. Carter |
| author_sort | Corey Baimel |
| collection | DOAJ |
| description | Summary: We examine synaptic connectivity and cocaine-evoked plasticity at specific networks within the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny neurons (MSNs) that project to either the ventral pallidum (D1+VP) or the ventral tegmental area (D1+VTA). We show that inputs from the ventral hippocampus (vHPC), but not the basolateral amygdala (BLA), are initially biased onto D1+VTA MSNs. However, repeated cocaine exposure eliminates the bias of vHPC inputs onto D1+VTA MSNs, while strengthening BLA inputs onto D1+VP MSNs. Our results reveal that connectivity and plasticity depend on the specific inputs and outputs of D1+ MSNs and highlight the complexity of cocaine-evoked circuit level adaptations in the NAc. : Baimel et al. examine how cocaine exposure alters specific circuits in the nucleus accumbens medial shell. They find that D1-expressing (D1+) medium spiny neurons projecting to ventral tegmental area and ventral pallidum are distinct populations. These two cell types differ in both their baseline synaptic connectivity and cocaine-evoked synaptic plasticity. Keywords: nucleus accumbens, cocaine sensitization, medium spiny neuron, spiny projection neuron, synaptic plasticity |
| first_indexed | 2024-12-22T04:00:20Z |
| format | Article |
| id | doaj.art-b58de2c76f9d43a1b87e76b947dd87de |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-22T04:00:20Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-b58de2c76f9d43a1b87e76b947dd87de2022-12-21T18:39:45ZengElsevierCell Reports2211-12472019-08-0128922562263.e3The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus AccumbensCorey Baimel0Laura M. McGarry1Adam G. Carter2Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA; Corresponding authorSummary: We examine synaptic connectivity and cocaine-evoked plasticity at specific networks within the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny neurons (MSNs) that project to either the ventral pallidum (D1+VP) or the ventral tegmental area (D1+VTA). We show that inputs from the ventral hippocampus (vHPC), but not the basolateral amygdala (BLA), are initially biased onto D1+VTA MSNs. However, repeated cocaine exposure eliminates the bias of vHPC inputs onto D1+VTA MSNs, while strengthening BLA inputs onto D1+VP MSNs. Our results reveal that connectivity and plasticity depend on the specific inputs and outputs of D1+ MSNs and highlight the complexity of cocaine-evoked circuit level adaptations in the NAc. : Baimel et al. examine how cocaine exposure alters specific circuits in the nucleus accumbens medial shell. They find that D1-expressing (D1+) medium spiny neurons projecting to ventral tegmental area and ventral pallidum are distinct populations. These two cell types differ in both their baseline synaptic connectivity and cocaine-evoked synaptic plasticity. Keywords: nucleus accumbens, cocaine sensitization, medium spiny neuron, spiny projection neuron, synaptic plasticityhttp://www.sciencedirect.com/science/article/pii/S2211124719309787 |
| spellingShingle | Corey Baimel Laura M. McGarry Adam G. Carter The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens Cell Reports |
| title | The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens |
| title_full | The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens |
| title_fullStr | The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens |
| title_full_unstemmed | The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens |
| title_short | The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens |
| title_sort | projection targets of medium spiny neurons govern cocaine evoked synaptic plasticity in the nucleus accumbens |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719309787 |
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