Research progress on metal ion-induced Parkinson's disease
Parkinson's disease (PD) is one of the hotspots in the research field of neurodegenerative diseases, and its pathogenesis is still controversial. Trace metal elements play an important role in normal growth and development of the human body. Metal ions can cross the blood-brain barrier and ente...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Committee of Journal of Environmental and Occupational Medicine
2023-11-01
|
| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM23138 |
| _version_ | 1797435404767461376 |
|---|---|
| author | Jingying WANG Binbin REN Suna MA Mengya GUAN Yueyue YANG Song WU |
| author_facet | Jingying WANG Binbin REN Suna MA Mengya GUAN Yueyue YANG Song WU |
| author_sort | Jingying WANG |
| collection | DOAJ |
| description | Parkinson's disease (PD) is one of the hotspots in the research field of neurodegenerative diseases, and its pathogenesis is still controversial. Trace metal elements play an important role in normal growth and development of the human body. Metal ions can cross the blood-brain barrier and enter the brain, leading to α-synapnuclein aggregation, mitochondrial dysfunction, and degeneration of dopaminergic neurons, and then inducing the occurrence of PD. This article mainly reviewed the potential mechanisms of metal elements in PD, discussed the role of metabolic imbalance of common trace metals (copper, iron, manganese, and zinc) in PD, and put forward new insights into the treatment of PD. |
| first_indexed | 2024-03-09T10:47:41Z |
| format | Article |
| id | doaj.art-b58e430f24d2488cb4b4239e758e6862 |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-03-09T10:47:41Z |
| publishDate | 2023-11-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-b58e430f24d2488cb4b4239e758e68622023-12-01T09:53:39ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822023-11-0140111334134010.11836/JEOM2313823138Research progress on metal ion-induced Parkinson's diseaseJingying WANG0Binbin REN1Suna MA2Mengya GUAN3Yueyue YANG4Song WU5Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, ChinaThe First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450000, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, ChinaParkinson's disease (PD) is one of the hotspots in the research field of neurodegenerative diseases, and its pathogenesis is still controversial. Trace metal elements play an important role in normal growth and development of the human body. Metal ions can cross the blood-brain barrier and enter the brain, leading to α-synapnuclein aggregation, mitochondrial dysfunction, and degeneration of dopaminergic neurons, and then inducing the occurrence of PD. This article mainly reviewed the potential mechanisms of metal elements in PD, discussed the role of metabolic imbalance of common trace metals (copper, iron, manganese, and zinc) in PD, and put forward new insights into the treatment of PD.http://www.jeom.org/article/cn/10.11836/JEOM23138parkinson's diseasemetalcopperironmanganesezinc |
| spellingShingle | Jingying WANG Binbin REN Suna MA Mengya GUAN Yueyue YANG Song WU Research progress on metal ion-induced Parkinson's disease 环境与职业医学 parkinson's disease metal copper iron manganese zinc |
| title | Research progress on metal ion-induced Parkinson's disease |
| title_full | Research progress on metal ion-induced Parkinson's disease |
| title_fullStr | Research progress on metal ion-induced Parkinson's disease |
| title_full_unstemmed | Research progress on metal ion-induced Parkinson's disease |
| title_short | Research progress on metal ion-induced Parkinson's disease |
| title_sort | research progress on metal ion induced parkinson s disease |
| topic | parkinson's disease metal copper iron manganese zinc |
| url | http://www.jeom.org/article/cn/10.11836/JEOM23138 |
| work_keys_str_mv | AT jingyingwang researchprogressonmetalioninducedparkinsonsdisease AT binbinren researchprogressonmetalioninducedparkinsonsdisease AT sunama researchprogressonmetalioninducedparkinsonsdisease AT mengyaguan researchprogressonmetalioninducedparkinsonsdisease AT yueyueyang researchprogressonmetalioninducedparkinsonsdisease AT songwu researchprogressonmetalioninducedparkinsonsdisease |