TIM‐3 expression induces resistance to PD‐1 inhibitor in G‐CSF‐producing lung spindle cell carcinoma: A case report

TIM‐3 expression induces resistance to PD‐1 inhibitor in G‐CSF‐producing lung spindle cell carcinoma: A case report

Abstract Lung spindle cell carcinoma is an aggressive subtype of pleomorphic lung cancer resistant to cytotoxic chemotherapy. Programmed cell death‐1 (PD‐1) inhibitors have been reported to have clinical effects in patients with spindle cell carcinoma; however, the resistance mechanism to PD‐1 inhib...

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Bibliographic Details
Main Authors: Fumiko Hayashi, Kazumasa Akagi, Hirokazu Taniguchi, Toyoshi Matsutake, Hiromi Kawahara, Ichiro Sekine, Hiroshi Gyotoku, Shinnosuke Takemoto, Hiroshi Soda, Kazuto Ashizawa, Hiroshi Mukae
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Thoracic Cancer
Subjects:
acquired resistance
immune checkpoint blockade
M2 macrophage
spindle cell carcinoma
TIM‐3
Online Access:https://doi.org/10.1111/1759-7714.15149

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